Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs.
C. Hebert, J. Delaney, B. Hemmelgarn, L. Lévesque, and S. Suissa. Pharmacoepidemiology and drug safety, 16 (8):
845-9(August 2007)4654<m:linebreak></m:linebreak>LR: 20081121; JID: 9208369; 0 (Central Nervous System Agents); 12794-10-4 (Benzodiazepines); CIN: Pharmacoepidemiol Drug Saf. 2007 Aug;16(8):850-3. PMID: 17636552; ppublish;<m:linebreak></m:linebreak>Mesures d'associació.
DOI: 10.1002/pds.1432
Abstract
PURPOSE: Contradictory results were published from two studies in the late 1990s about the effects of long half-life benzodiazepine use on the risk of motor vehicle crashes (MVCs) in the elderly. The use of different study designs could explain the differences observed in these studies. METHODS: The results of an unmatched case-control study were compared to those of a case-crossover study using the same prescription claims database to determine whether the current use of benzodiazepines increased the risk of MVCs. RESULTS: There were 5579 cases and 12 911 controls identified between the years 1990 and 1993 in the province of Quebec, Canada. The case-control approach demonstrated an increased rate of injurious MVC associated with the current use of long-acting benzodiazepines odds ratio (OR) 1.45; 95% confidence interval (CI): 1.12-1.88. The case-crossover approach applied to all cases did not show any association OR 0.99; 95%CI: 0.83-1.19. However, among the cases restricted to subjects with four or less prescriptions filled in the previous year, corresponding more to transient exposures, the OR was elevated OR 1.53; 95%CI: 1.08-2.16. CONCLUSIONS: Differences in study design and analysis may explain some of the discrepancies in previous results. Both study designs provide evidence that long-acting benzodiazepines appear to be associated with an increased risk of MVC.
%0 Journal Article
%1 Hebert2007
%A Hebert, Caroline
%A Delaney, J A C
%A Hemmelgarn, Brenda
%A Lévesque, Linda E
%A Suissa, Samy
%D 2007
%J Pharmacoepidemiology and drug safety
%K 80andover Accidents AgeFactors Aged AutomobileDriving Benzodiazepines Benzodiazepines:adverseeffects Benzodiazepines:pharmacokinetics Case-ControlStudies CentralNervousSystemAgents CentralNervousSystemAgents:adverseeffects CentralNervousSystemAgents:pharmacokinetics Cross-OverStudies Databases EpidemiologicResearchDesign Factual Female Half-Life Humans Male OddsRatio Pharmacoepidemiology Pharmacoepidemiology:methods Quebec Quebec:epidemiology ReproducibilityofResults Risk Traffic Traffic:statistics&numericaldata
%N 8
%P 845-9
%R 10.1002/pds.1432
%T Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs.
%U http://www.ncbi.nlm.nih.gov/pubmed/17563091
%V 16
%X PURPOSE: Contradictory results were published from two studies in the late 1990s about the effects of long half-life benzodiazepine use on the risk of motor vehicle crashes (MVCs) in the elderly. The use of different study designs could explain the differences observed in these studies. METHODS: The results of an unmatched case-control study were compared to those of a case-crossover study using the same prescription claims database to determine whether the current use of benzodiazepines increased the risk of MVCs. RESULTS: There were 5579 cases and 12 911 controls identified between the years 1990 and 1993 in the province of Quebec, Canada. The case-control approach demonstrated an increased rate of injurious MVC associated with the current use of long-acting benzodiazepines odds ratio (OR) 1.45; 95% confidence interval (CI): 1.12-1.88. The case-crossover approach applied to all cases did not show any association OR 0.99; 95%CI: 0.83-1.19. However, among the cases restricted to subjects with four or less prescriptions filled in the previous year, corresponding more to transient exposures, the OR was elevated OR 1.53; 95%CI: 1.08-2.16. CONCLUSIONS: Differences in study design and analysis may explain some of the discrepancies in previous results. Both study designs provide evidence that long-acting benzodiazepines appear to be associated with an increased risk of MVC.
%@ 1053-8569
@article{Hebert2007,
abstract = {PURPOSE: Contradictory results were published from two studies in the late 1990s about the effects of long half-life benzodiazepine use on the risk of motor vehicle crashes (MVCs) in the elderly. The use of different study designs could explain the differences observed in these studies. METHODS: The results of an unmatched case-control study were compared to those of a case-crossover study using the same prescription claims database to determine whether the current use of benzodiazepines increased the risk of MVCs. RESULTS: There were 5579 cases and 12 911 controls identified between the years 1990 and 1993 in the province of Quebec, Canada. The case-control approach demonstrated an increased rate of injurious MVC associated with the current use of long-acting benzodiazepines [odds ratio (OR) 1.45; 95% confidence interval (CI): 1.12-1.88]. The case-crossover approach applied to all cases did not show any association [OR 0.99; 95%CI: 0.83-1.19]. However, among the cases restricted to subjects with four or less prescriptions filled in the previous year, corresponding more to transient exposures, the OR was elevated [OR 1.53; 95%CI: 1.08-2.16]. CONCLUSIONS: Differences in study design and analysis may explain some of the discrepancies in previous results. Both study designs provide evidence that long-acting benzodiazepines appear to be associated with an increased risk of MVC.},
added-at = {2023-02-03T11:44:35.000+0100},
author = {Hebert, Caroline and Delaney, J A C and Hemmelgarn, Brenda and Lévesque, Linda E and Suissa, Samy},
biburl = {https://www.bibsonomy.org/bibtex/273bf5308f588bed730007a9cb0750ac8/jepcastel},
city = {Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada.},
doi = {10.1002/pds.1432},
interhash = {78b1fdf94d8c1eed36e41e1d6baa7379},
intrahash = {73bf5308f588bed730007a9cb0750ac8},
isbn = {1053-8569},
issn = {1053-8569},
journal = {Pharmacoepidemiology and drug safety},
keywords = {80andover Accidents AgeFactors Aged AutomobileDriving Benzodiazepines Benzodiazepines:adverseeffects Benzodiazepines:pharmacokinetics Case-ControlStudies CentralNervousSystemAgents CentralNervousSystemAgents:adverseeffects CentralNervousSystemAgents:pharmacokinetics Cross-OverStudies Databases EpidemiologicResearchDesign Factual Female Half-Life Humans Male OddsRatio Pharmacoepidemiology Pharmacoepidemiology:methods Quebec Quebec:epidemiology ReproducibilityofResults Risk Traffic Traffic:statistics&numericaldata},
month = {8},
note = {4654<m:linebreak></m:linebreak>LR: 20081121; JID: 9208369; 0 (Central Nervous System Agents); 12794-10-4 (Benzodiazepines); CIN: Pharmacoepidemiol Drug Saf. 2007 Aug;16(8):850-3. PMID: 17636552; ppublish;<m:linebreak></m:linebreak>Mesures d'associació},
number = 8,
pages = {845-9},
pmid = {17563091},
timestamp = {2023-02-03T11:44:35.000+0100},
title = {Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17563091},
volume = 16,
year = 2007
}