%0 Journal Article %1 Hebert2007 %A Hebert, Caroline %A Delaney, J A C %A Hemmelgarn, Brenda %A Lévesque, Linda E %A Suissa, Samy %D 2007 %J Pharmacoepidemiology and drug safety %K 80andover Accidents AgeFactors Aged AutomobileDriving Benzodiazepines Benzodiazepines:adverseeffects Benzodiazepines:pharmacokinetics Case-ControlStudies CentralNervousSystemAgents CentralNervousSystemAgents:adverseeffects CentralNervousSystemAgents:pharmacokinetics Cross-OverStudies Databases EpidemiologicResearchDesign Factual Female Half-Life Humans Male OddsRatio Pharmacoepidemiology Pharmacoepidemiology:methods Quebec Quebec:epidemiology ReproducibilityofResults Risk Traffic Traffic:statistics&numericaldata %N 8 %P 845-9 %R 10.1002/pds.1432 %T Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs. %U http://www.ncbi.nlm.nih.gov/pubmed/17563091 %V 16 %X PURPOSE: Contradictory results were published from two studies in the late 1990s about the effects of long half-life benzodiazepine use on the risk of motor vehicle crashes (MVCs) in the elderly. The use of different study designs could explain the differences observed in these studies. METHODS: The results of an unmatched case-control study were compared to those of a case-crossover study using the same prescription claims database to determine whether the current use of benzodiazepines increased the risk of MVCs. RESULTS: There were 5579 cases and 12 911 controls identified between the years 1990 and 1993 in the province of Quebec, Canada. The case-control approach demonstrated an increased rate of injurious MVC associated with the current use of long-acting benzodiazepines odds ratio (OR) 1.45; 95% confidence interval (CI): 1.12-1.88. The case-crossover approach applied to all cases did not show any association OR 0.99; 95%CI: 0.83-1.19. However, among the cases restricted to subjects with four or less prescriptions filled in the previous year, corresponding more to transient exposures, the OR was elevated OR 1.53; 95%CI: 1.08-2.16. CONCLUSIONS: Differences in study design and analysis may explain some of the discrepancies in previous results. Both study designs provide evidence that long-acting benzodiazepines appear to be associated with an increased risk of MVC. %@ 1053-8569

@article{Hebert2007, abstract = {PURPOSE: Contradictory results were published from two studies in the late 1990s about the effects of long half-life benzodiazepine use on the risk of motor vehicle crashes (MVCs) in the elderly. The use of different study designs could explain the differences observed in these studies. METHODS: The results of an unmatched case-control study were compared to those of a case-crossover study using the same prescription claims database to determine whether the current use of benzodiazepines increased the risk of MVCs. RESULTS: There were 5579 cases and 12 911 controls identified between the years 1990 and 1993 in the province of Quebec, Canada. The case-control approach demonstrated an increased rate of injurious MVC associated with the current use of long-acting benzodiazepines [odds ratio (OR) 1.45; 95% confidence interval (CI): 1.12-1.88]. The case-crossover approach applied to all cases did not show any association [OR 0.99; 95%CI: 0.83-1.19]. However, among the cases restricted to subjects with four or less prescriptions filled in the previous year, corresponding more to transient exposures, the OR was elevated [OR 1.53; 95%CI: 1.08-2.16]. CONCLUSIONS: Differences in study design and analysis may explain some of the discrepancies in previous results. Both study designs provide evidence that long-acting benzodiazepines appear to be associated with an increased risk of MVC.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Hebert, Caroline and Delaney, J A C and Hemmelgarn, Brenda and Lévesque, Linda E and Suissa, Samy}, biburl = {https://www.bibsonomy.org/bibtex/273bf5308f588bed730007a9cb0750ac8/jepcastel}, city = {Division of Clinical Epidemiology, McGill University Health Center, Montreal, Canada.}, doi = {10.1002/pds.1432}, interhash = {78b1fdf94d8c1eed36e41e1d6baa7379}, intrahash = {73bf5308f588bed730007a9cb0750ac8}, isbn = {1053-8569}, issn = {1053-8569}, journal = {Pharmacoepidemiology and drug safety}, keywords = {80andover Accidents AgeFactors Aged AutomobileDriving Benzodiazepines Benzodiazepines:adverseeffects Benzodiazepines:pharmacokinetics Case-ControlStudies CentralNervousSystemAgents CentralNervousSystemAgents:adverseeffects CentralNervousSystemAgents:pharmacokinetics Cross-OverStudies Databases EpidemiologicResearchDesign Factual Female Half-Life Humans Male OddsRatio Pharmacoepidemiology Pharmacoepidemiology:methods Quebec Quebec:epidemiology ReproducibilityofResults Risk Traffic Traffic:statistics&numericaldata}, month = {8}, note = {4654<m:linebreak></m:linebreak>LR: 20081121; JID: 9208369; 0 (Central Nervous System Agents); 12794-10-4 (Benzodiazepines); CIN: Pharmacoepidemiol Drug Saf. 2007 Aug;16(8):850-3. PMID: 17636552; ppublish;<m:linebreak></m:linebreak>Mesures d&#039;associació}, number = 8, pages = {845-9}, pmid = {17563091}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17563091}, volume = 16, year = 2007 }