Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1, 2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.
%0 Journal Article
%1 Jeong2001Lethality
%A Jeong, H.
%A Mason, S. P.
%A Barabási, A. L.
%A Oltvai, Z. N.
%D 2001
%I Nature Publishing Group
%J Nature
%K protein\_interaction, proteins networks biological-networks centrality
%N 6833
%P 41--42
%R 10.1038/35075138
%T Lethality and centrality in protein networks
%U http://dx.doi.org/10.1038/35075138
%V 411
%X Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1, 2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.
@article{Jeong2001Lethality,
abstract = {{Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1, 2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.}},
added-at = {2019-06-10T14:53:09.000+0200},
archiveprefix = {arXiv},
author = {Jeong, H. and Mason, S. P. and Barab\'{a}si, A. L. and Oltvai, Z. N.},
biburl = {https://www.bibsonomy.org/bibtex/2f541068d7a941655ebab6f50cd964a52/nonancourt},
citeulike-article-id = {478707},
citeulike-linkout-0 = {http://arxiv.org/abs/cond-mat/0105306},
citeulike-linkout-1 = {http://arxiv.org/pdf/cond-mat/0105306},
citeulike-linkout-2 = {http://dx.doi.org/10.1038/35075138},
citeulike-linkout-3 = {http://dx.doi.org/10.1038/411041a0},
citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/11333967},
citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=11333967},
day = 03,
doi = {10.1038/35075138},
eprint = {cond-mat/0105306},
interhash = {06ccaa76b0e843888c00181d87671bb6},
intrahash = {f541068d7a941655ebab6f50cd964a52},
issn = {0028-0836},
journal = {Nature},
keywords = {protein\_interaction, proteins networks biological-networks centrality},
month = may,
number = 6833,
pages = {41--42},
pmid = {11333967},
posted-at = {2008-12-11 10:48:29},
priority = {3},
publisher = {Nature Publishing Group},
timestamp = {2019-08-01T16:10:39.000+0200},
title = {{Lethality and centrality in protein networks}},
url = {http://dx.doi.org/10.1038/35075138},
volume = 411,
year = 2001
}