%0 Journal Article %1 Jeong2001Lethality %A Jeong, H. %A Mason, S. P. %A Barabási, A. L. %A Oltvai, Z. N. %D 2001 %I Nature Publishing Group %J Nature %K protein\_interaction, proteins networks biological-networks centrality %N 6833 %P 41--42 %R 10.1038/35075138 %T Lethality and centrality in protein networks %U http://dx.doi.org/10.1038/35075138 %V 411 %X Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1, 2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.

@article{Jeong2001Lethality, abstract = {{Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1, 2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeast Saccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.}}, added-at = {2019-06-10T14:53:09.000+0200}, archiveprefix = {arXiv}, author = {Jeong, H. and Mason, S. P. and Barab\'{a}si, A. L. and Oltvai, Z. N.}, biburl = {https://www.bibsonomy.org/bibtex/2f541068d7a941655ebab6f50cd964a52/nonancourt}, citeulike-article-id = {478707}, citeulike-linkout-0 = {http://arxiv.org/abs/cond-mat/0105306}, citeulike-linkout-1 = {http://arxiv.org/pdf/cond-mat/0105306}, citeulike-linkout-2 = {http://dx.doi.org/10.1038/35075138}, citeulike-linkout-3 = {http://dx.doi.org/10.1038/411041a0}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/11333967}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=11333967}, day = 03, doi = {10.1038/35075138}, eprint = {cond-mat/0105306}, interhash = {06ccaa76b0e843888c00181d87671bb6}, intrahash = {f541068d7a941655ebab6f50cd964a52}, issn = {0028-0836}, journal = {Nature}, keywords = {protein\_interaction, proteins networks biological-networks centrality}, month = may, number = 6833, pages = {41--42}, pmid = {11333967}, posted-at = {2008-12-11 10:48:29}, priority = {3}, publisher = {Nature Publishing Group}, timestamp = {2019-08-01T16:10:39.000+0200}, title = {{Lethality and centrality in protein networks}}, url = {http://dx.doi.org/10.1038/35075138}, volume = 411, year = 2001 }