Isolation and identification of one chemical compound from the seeds of soursop, Annona muricata (Annonaceae) based on bioactivity-guided fractionation by the Brine Shrimp Lethality Assay (BSLA) have been done. The powder of soursop seed was extracted successively with n-hexane, chloroform, and methanol then the methanol extract was partitioned with ethylacetate water. Isolation and purification of ethylacetate extracts were carried out by column chromatography (SiO2; i. n-hexane-chloroform = 15:1 ~ 1:1 gave one pure isolatedcompound. Based on Ultra Violet (UV), Infra-Red (IR), Nuclear Magnetic Resonance (NMR), and mass spectra (LC-MS/MS), the isolated Fr-4 was an acetogenin compound, sabadelin which had a weak cytotoxicity LC50 of 487 ppm.
%0 Journal Article
%1 rudi_kartika_2024_10615261
%A KARTIKA, RUDI
%A SULASTRI, LILIK
%A KAMAL, ANDI SAPTAJI
%A TARIGAN, ELSERA BR
%A SIMANJUNTAK, PARTOMUAN
%D 2024
%J GSC Advanced Research and Reviews
%K Annona muricata
%N 2
%P 240–246
%R 10.30574/gscarr.2023.17.2.0446
%T Identification of acetogenin compound, sabadelin from soursop seeds, Annona muricata (Annonaceae)
%U https://gsconlinepress.com/journals/gscarr/content/identification-acetogenin-compound-sabadelin-soursop-seeds-annona-muricata-annonaceae
%V 17
%X Isolation and identification of one chemical compound from the seeds of soursop, Annona muricata (Annonaceae) based on bioactivity-guided fractionation by the Brine Shrimp Lethality Assay (BSLA) have been done. The powder of soursop seed was extracted successively with n-hexane, chloroform, and methanol then the methanol extract was partitioned with ethylacetate water. Isolation and purification of ethylacetate extracts were carried out by column chromatography (SiO2; i. n-hexane-chloroform = 15:1 ~ 1:1 gave one pure isolatedcompound. Based on Ultra Violet (UV), Infra-Red (IR), Nuclear Magnetic Resonance (NMR), and mass spectra (LC-MS/MS), the isolated Fr-4 was an acetogenin compound, sabadelin which had a weak cytotoxicity LC50 of 487 ppm.
@article{rudi_kartika_2024_10615261,
abstract = {Isolation and identification of one chemical compound from the seeds of soursop, Annona muricata (Annonaceae) based on bioactivity-guided fractionation by the Brine Shrimp Lethality Assay (BSLA) have been done. The powder of soursop seed was extracted successively with n-hexane, chloroform, and methanol then the methanol extract was partitioned with ethylacetate water. Isolation and purification of ethylacetate extracts were carried out by column chromatography [(SiO2; i. n-hexane-chloroform = 15:1 ~ 1:1 gave one pure isolatedcompound. Based on Ultra Violet (UV), Infra-Red (IR), Nuclear Magnetic Resonance (NMR), and mass spectra (LC-MS/MS), the isolated Fr-4 was an acetogenin compound, sabadelin which had a weak cytotoxicity LC50 of 487 ppm.},
added-at = {2024-03-14T12:07:35.000+0100},
author = {KARTIKA, RUDI and SULASTRI, LILIK and KAMAL, ANDI SAPTAJI and TARIGAN, ELSERA BR and SIMANJUNTAK, PARTOMUAN},
biburl = {https://www.bibsonomy.org/bibtex/2b9dc3d70dc865101d64a2f74d58df643/gscarrjournal},
doi = {10.30574/gscarr.2023.17.2.0446},
interhash = {5ce03de4e2f415a2a5da7964efe4d757},
intrahash = {b9dc3d70dc865101d64a2f74d58df643},
issn = {2582-4597},
journal = {GSC Advanced Research and Reviews},
keywords = {Annona muricata},
month = feb,
number = 2,
pages = {240–246},
timestamp = {2024-03-14T12:07:35.000+0100},
title = {Identification of acetogenin compound, sabadelin from soursop seeds, Annona muricata (Annonaceae)},
url = {https://gsconlinepress.com/journals/gscarr/content/identification-acetogenin-compound-sabadelin-soursop-seeds-annona-muricata-annonaceae},
volume = 17,
year = 2024
}