Central neuropeptides, including corticotropin releasing factor and perhaps substance P as well, initiate a systemic stress mobilization response by activating the sympathetic nervous system, hypothalamic pituitary axis, and the renin angiotensin system,
A nonspecific immune reaction inducing a syndrome profile of fever, pain, anxiety, depression, reclusivity, anorexia, stress hormones, triggered by signals in the brain’s hypothalamus; body’s attempt to produce & preserve energy; cells secrete proinfl