Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
E. Adachi, Y. Kazoe, Y. Sato, Y. Suzuki, T. Urano, T. Ueyama, N. Saito, V. Nikolaev, M. Lohse, M. Tominaga and 1 other author(s). Pflugers Arch, 459 (1):
227-34(November 2009)Adachi, Eisuke Kazoe, Yutaka Sato, Yohei Suzuki, Yuko Urano, Tetsumei
Ueyama, Takehiko Saito, Naoaki Nikolaev, Viacheslav O Lohse, Martin
J Tominaga, Makoto Mogami, Hideo Research Support, Non-U.S. Gov't
Germany Pflugers Archiv : European journal of physiology Pflugers
Arch. 2009 Nov;459(1):227-34. Epub 2009 Aug 13..
J. Benovic, J. Onorato, J. Arriza, W. Stone, M. Lohse, N. Jenkins, D. Gilbert, N. Copeland, M. Caron, and R. Lefkowitz. J Biol Chem, 266 (23):
14939-46(August 1991)Benovic, J L Onorato, J J Arriza, J L Stone, W C Lohse, M Jenkins,
N A Gilbert, D J Copeland, N G Caron, M G Lefkowitz, R J GM44944/GM/NIGMS
NIH HHS/United States HL16037/HL/NHLBI NIH HHS/United States N01-CO-74101/CO/NCI
NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United
states The Journal of biological chemistry J Biol Chem. 1991 Aug
15;266(23):14939-46..
J. Benovic, J. Onorato, M. Lohse, H. Dohlman, C. Staniszewski, M. Caron, and R. Lefkowitz. Br J Clin Pharmacol, (1990)Benovic, J L Onorato, J Lohse, M J Dohlman, H G Staniszewski, C Caron,
M G Lefkowitz, R J England British journal of clinical pharmacology
Br J Clin Pharmacol. 1990;30 Suppl 1:3S-12S..
I. Boekhoff, K. Touhara, S. Danner, J. Inglese, M. Lohse, H. Breer, and R. Lefkowitz. J Biol Chem, 272 (7):
4606-12(February 1997)Boekhoff, I Touhara, K Danner, S Inglese, J Lohse, M J Breer, H Lefkowitz,
R J HL16037/HL/NHLBI NIH HHS/United States Research Support, Non-U.S.
Gov't Research Support, U.S. Gov't, P.H.S. United states The Journal
of biological chemistry J Biol Chem. 1997 Feb 14;272(7):4606-12..
M. Castro, F. Dicker, J. Vilardaga, C. Krasel, M. Bernhardt, and M. Lohse. Endocrinology, 143 (10):
3854-65(October 2002)Castro, Marian Dicker, Frank Vilardaga, Jean-Pierre Krasel, Cornelius
Bernhardt, Manfred Lohse, Martin J Research Support, Non-U.S. Gov't
United States Endocrinology Endocrinology. 2002 Oct;143(10):3854-65..