"Just launched at work: Faces of the Fallen, a browsable database of U.S. service members who've died in Iraq and Afghanistan... Now we've given it the full browsable-database treatment, with permalinks for everything."
PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.