The COVID-19 lockdown has resulted in psychological distress and highlighted vulnerable groups such as those with previous or current mental health difficulties. Supporting the mental health needs of children and adolescents at risk is key. Clinical guidelines to alleviate the negative effects of COVID-19 lockdown and public health strategies to support this population need to be developed. Open access.
The authors concluded that medical students and junior doctors suffered significantly from both the inherent medicine stressors, but also the additional burdens brought onto the healthcare system during COVID-19, in a culture of stress around mental health difficulties that promotes presenteeism and acceptance of unsatisfactory working conditions.
In this umbrella review, we synthesise global evidence on the impact of COVID-19 on the mental health of CYP from existing systematic reviews with and/or without meta-analysis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
COVID-19 World is the best website to track COVID-19 world data like country wise data and map it also provide useful links most of the effected countries
Based on 2021 Centers for Disease Control and Prevention (CDC) data, more than 30% of US adolescents experienced poor mental health during the COVID-19 pandemic. ... Moreover, as we emerge from the social and physical distancing required during the COVID-19 pandemic, we also emerge into an era when the social isolation experienced by adolescents during the pandemic is compounded by growing fears and anxieties.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are speculated to have originated in bats. The mechanisms by which these viruses are maintained in individuals or populations of reservoir bats remain an enigma. Mathematical models have predicted long-term persistent infection with low levels of periodic shedding as a likely route for virus maintenance and spillover from bats. In this study, we tested the hypothesis that bat cells and MERS coronavirus (CoV) can co-exist in vitro. To test our hypothesis, we established a long-term coronavirus infection model of bat cells that are persistently infected with MERS-CoV. We infected cells from Eptesicus fuscus with MERS-CoV and maintained them in culture for at least 126 days. We characterized the persistently infected cells by detecting virus particles, protein and transcripts. Basal levels of type I interferon in the long-term infected bat cells were higher, relative to uninfected cells, and disrupting the interferon response in persistently infected bat cells increased virus replication. By sequencing the whole genome of MERS-CoV from persistently infected bat cells, we identified that bat cells repeatedly selected for viral variants that contained mutations in the viral open reading frame 5 (ORF5) protein. Furthermore, bat cells that were persistently infected with ΔORF5 MERS-CoV were resistant to superinfection by wildtype virus, likely due to reduced levels of the virus receptor, dipeptidyl peptidase 4 (DPP4) and higher basal levels of interferon in these cells. In summary, our study provides evidence for a model of coronavirus persistence in bats, along with the establishment of a unique persistently infected cell culture model to study MERS-CoV-bat interactions.
H. Dong, V. Suárez-Paniagua, W. Whiteley, and H. Wu. (2020)cite arxiv:2010.15728Comment: Structured abstract in full text, 17 pages, 5 figures, 4 supplementary materials (3 extra pages), submitted to Journal of Biomedical Informatics.