The best evidence for efficacy from adequately designed randomized controlled trials (RCTs) is available for Coccinia indica and American ginseng. Chromium has been the most widely studied supplement. Other supplements with positive preliminary results in
Written records of the Chinese experience with cancer treatment date back to the time of the Yellow Emperor's Inner Classic (Huang di nei jing), 2nd century BC. This ancient book addresses symptoms similar to those of esophogeal, uterine and bone cancer.