tag :: Endothelial Research

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1Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
D. Fukumura, and R. Jain. Microvasc.Res., 74 (2-3): 72-84 (2007)
15 years ago by @kanefendt
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&
Angiogenesis
Animals
Blood
Endothelial
Factors
Growth
Humans
Inhibitors
Laboratories
Neoplasms
Neovascularization
Pathologic
Research
Vascular
Vessels
antagonists
blood
cells
drug
inhibitors
pathology
supply
therapeutic
therapy
use
&AngiogenesisAnimalsBloodEndothelialFactorsGrowthHumansInhibitorsLaboratoriesNeoplasmsNeovascularizationPathologicResearchVascularVesselsantagonistsbloodcellsdruginhibitorspathologysupplytherapeutictherapyuse
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1Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. Luft and 2 other author(s). Circ.Res., 101 (3): 268-276 (2007)
15 years ago by @kanefendt
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Adhesion
Albuminuria
Angiotensin
Animals
Atherosclerosis
B
Blood
C57BL
Cardiovascular
Cell
Cells
Chain
Chloride
Cultured
Dietary
Diseases
Endothelial
Ester
Expression
Factor-alpha
Fusion
Gene
Humans
Hypertension
I-kappa
II
III
Inbred
Inflammation
Intercellular
Kidney
Methyl
Mice
Models
Molecule-1
NF-kappa
NG-Nitroarginine
Necrosis
Nephritis
Nitric
Organ
Oxide
Polymerase
Pressure
Proteins
Reaction
Receptor
Recombinant
Regulation
Research
Reverse
Signal
Sodium
Specificity
Synthase
TIE-1
Transcriptase
Transduction
Transgenic
Tumor
Type
Vascular
antagonists
biosynthesis
blood
cells
complications
control
etiology
genetics
inhibitors
metabolism
physiology
physiopathology
prevention
protein
toxicity
&AdhesionAlbuminuriaAngiotensinAnimalsAtherosclerosisBBloodC57BLCardiovascularCellCellsChainChlorideCulturedDietaryDiseasesEndothelialEsterExpressionFactor-alphaFusionGeneHumansHypertensionI-kappaIIIIIInbredInflammationIntercellularKidneyMethylMiceModelsMolecule-1NF-kappaNG-NitroarginineNecrosisNephritisNitricOrganOxidePolymerasePressureProteinsReactionReceptorRecombinantRegulationResearchReverseSignalSodiumSpecificitySynthaseTIE-1TranscriptaseTransductionTransgenicTumorTypeVascularantagonistsbiosynthesisbloodcellscomplicationscontroletiologygeneticsinhibitorsmetabolismphysiologyphysiopathologypreventionproteintoxicity
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1Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer
C. Kut, G. Mac, and A. Popel. Br.J.Cancer, 97 (7): 978-985 (2007)
15 years ago by @kanefendt
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A
Assay
Distribution
Endothelial
Enzyme-Linked
Factor
Growth
Human
Humans
Immunosorbent
Neoplasms
Pharmacokinetics
Prognosis
Research
Tissue
Vascular
blood
cells
diagnosis
metabolism
pathology
protein
AAssayDistributionEndothelialEnzyme-LinkedFactorGrowthHumanHumansImmunosorbentNeoplasmsPharmacokineticsPrognosisResearchTissueVascularbloodcellsdiagnosismetabolismpathologyprotein
(0)
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1Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
P. Laakkonen, M. Waltari, T. Holopainen, T. Takahashi, B. Pytowski, P. Steiner, D. Hicklin, K. Persaud, J. Tonra, L. Witte and 1 other author(s). Cancer Res., 67 (2): 593-599 (2007)
15 years ago by @kanefendt
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Animals
Antibodies
Antitumor
Assays
BALB
Binding
C
Cell
D
Endothelial
Factor
Growth
Human
Humans
Immunohistochemistry
Inbred
Ligands
Mice
Model
Monoclonal
Neoplasms
Neovascularization
Nude
Pathologic
Processes
Receptor-3
Research
Vascular
Xenograft
analysis
antagonists
blood
immunology
inhibitors
metabolism
pharmacology
supply
therapy
&AnimalsAntibodiesAntitumorAssaysBALBBindingCCellDEndothelialFactorGrowthHumanHumansImmunohistochemistryInbredLigandsMiceModelMonoclonalNeoplasmsNeovascularizationNudePathologicProcessesReceptor-3ResearchVascularXenograftanalysisantagonistsbloodimmunologyinhibitorsmetabolismpharmacologysupplytherapy
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1Molecular mechanisms of lymphatic vascular development
T. Makinen, C. Norrmen, and T. Petrova. Cell Mol.Life Sci., 64 (15): 1915-1929 (2007)
15 years ago by @kanefendt
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A
Angiopoietins
Animals
Biological
Cells
Cultured
Endothelial
Factor
Growth
Human
Humans
Inflammation
Lymphangiogenesis
Lymphatic
Lymphedema
Models
Proteins
Receptors
Research
Substances
TIE
Transport
Vascular
Vesicular
Vessels
analysis
cells
cytology
physiology
protein
AAngiopoietinsAnimalsBiologicalCellsCulturedEndothelialFactorGrowthHumanHumansInflammationLymphangiogenesisLymphaticLymphedemaModelsProteinsReceptorsResearchSubstancesTIETransportVascularVesicularVesselsanalysiscellscytologyphysiologyprotein
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1Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. Deprimo, and C. Bello. Ann.Oncol, (2007)
15 years ago by @kanefendt
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Angiogenesis
Biological
Cells
Endothelial
Growth
Humans
Indoles
Inhibitors
Laboratories
Markers
Neoplasms
Neovascularization
Pathologic
Proteins
Pyrroles
Research
Tumor
blood
cells
diagnosis
drug
effects
metabolism
methods
pathology
pharmacology
protein
response
supply
therapeutic
therapy
use
AngiogenesisBiologicalCellsEndothelialGrowthHumansIndolesInhibitorsLaboratoriesMarkersNeoplasmsNeovascularizationPathologicProteinsPyrrolesResearchTumorbloodcellsdiagnosisdrugeffectsmetabolismmethodspathologypharmacologyproteinresponsesupplytherapeutictherapyuse
(0)
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1Molecular and cellular biomarkers for angiogenesis in clinical oncology
F. Bertolini, P. Mancuso, Y. Shaked, and R. Kerbel. Drug Discov.Today, 12 (19-20): 806-812 (2007)
15 years ago by @kanefendt
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Angiogenesis
Antigens
Biological
Cells
Endothelial
Humans
Inhibitors
Markers
Microcirculation
Neoplasms
Neovascularization
Pathologic
Research
Tumor
blood
cells
diagnosis
drug
metabolism
pathology
pharmacology
supply
therapeutic
therapy
use
AngiogenesisAntigensBiologicalCellsEndothelialHumansInhibitorsMarkersMicrocirculationNeoplasmsNeovascularizationPathologicResearchTumorbloodcellsdiagnosisdrugmetabolismpathologypharmacologysupplytherapeutictherapyuse
(0)
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1Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. Ebos, C. Lee, J. Christensen, A. Mutsaers, and R. Kerbel. Proc.Natl.Acad.Sci.U.S.A, 104 (43): 17069-17074 (2007)
15 years ago by @kanefendt
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&
A
Administration
Agents
Angiogenesis
Animals
Antineoplastic
Antitumor
Assays
Blood
Cell
Dose-Response
Drug
Endothelial
Factor
Female
Growth
Humans
Hypoxia
Indoles
Inducing
Line
Mice
Model
Neoplasms
Organ
Outcome
Placenta
Pregnancy
Proteins
Pyrroles
RANGE
Receptor-2
Relationship
Research
Schedule
Scid
Specificity
Treatment
Tumor
Tyrosine
Vascular
Xenograft
administration
blood
dosage
drug
effects
metabolism
pathology
pharmacology
protein
response
therapy
toxicity
&AAdministrationAgentsAngiogenesisAnimalsAntineoplasticAntitumorAssaysBloodCellDose-ResponseDrugEndothelialFactorFemaleGrowthHumansHypoxiaIndolesInducingLineMiceModelNeoplasmsOrganOutcomePlacentaPregnancyProteinsPyrrolesRANGEReceptor-2RelationshipResearchScheduleScidSpecificityTreatmentTumorTyrosineVascularXenograftadministrationblooddosagedrugeffectsmetabolismpathologypharmacologyproteinresponsetherapytoxicity
(0)
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1Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma
S. Juttner, C. Wissmann, T. Jons, M. Vieth, J. Hertel, S. Gretschel, P. Schlag, W. Kemmner, and M. Hocker. J.Clin.Oncol., 24 (2): 228-240 (2006)
15 years ago by @kanefendt
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80
Adenocarcinoma
Adult
Aged
Antibodies
C
Cell
Chemistry
D
Disease-Free
Endothelial
Factor
Growth
Humans
Immunohistochemistry
Laboratories
Line
Lymphatic
Messenger
Metastasis
Middle
Neoplasms
Prognosis
RNA
Receptor-3
Research
Stomach
Survival
Tumor
Vascular
analysis
and
blood
genetics
identify
methods
mortality
over
supply
80AdenocarcinomaAdultAgedAntibodiesCCellChemistryDDisease-FreeEndothelialFactorGrowthHumansImmunohistochemistryLaboratoriesLineLymphaticMessengerMetastasisMiddleNeoplasmsPrognosisRNAReceptor-3ResearchStomachSurvivalTumorVascularanalysisandbloodgeneticsidentifymethodsmortalityoversupply
(0)
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1VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
A. Gampel, L. Moss, M. Jones, V. Brunton, J. Norman, and H. Mellor. Blood, 108 (8): 2624-2631 (2006)
15 years ago by @kanefendt
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A
Active
Adult
Biological
Blood
Cell
Cells
Compartmentation
Cultured
Endosomes
Endothelial
Factor
GTP-Binding
Growth
Humans
Kinases
Laboratories
Lysosomes
Membrane
Plasma
Proteins
Receptor-2
Recombinant
Research
Transport
Tyrosine
Vascular
Vessels
blood
cells
cytology
drug
effects
metabolism
pharmacology
protein
rab4
response
src-Family
AActiveAdultBiologicalBloodCellCellsCompartmentationCulturedEndosomesEndothelialFactorGTP-BindingGrowthHumansKinasesLaboratoriesLysosomesMembranePlasmaProteinsReceptor-2RecombinantResearchTransportTyrosineVascularVesselsbloodcellscytologydrugeffectsmetabolismpharmacologyproteinrab4responsesrc-Family
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1Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
A. Morabito, M. De, M. Di, N. Normanno, and F. Perrone. Oncologist., 11 (7): 753-764 (2006)
15 years ago by @kanefendt
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&
A
Angiogenesis
Clinical
Endothelial
Factor
Growth
Human
Humans
Inhibitors
Kinase
Kinases
Lung
Neoplasms
Piperidines
Protein
Protein-Tyrosine
Proteins
Quinazolines
Receptors
Research
Safety
Topic
Trials
Tyrosine
Vascular
antagonists
as
drug
inhibitors
metabolism
protein
therapeutic
therapy
use
&AAngiogenesisClinicalEndothelialFactorGrowthHumanHumansInhibitorsKinaseKinasesLungNeoplasmsPiperidinesProteinProtein-TyrosineProteinsQuinazolinesReceptorsResearchSafetyTopicTrialsTyrosineVascularantagonistsasdruginhibitorsmetabolismproteintherapeutictherapyuse
(0)
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1Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
M. Shibuya, and L. Claesson-Welsh. Exp.Cell Res., 312 (5): 549-560 (2006)
15 years ago by @kanefendt
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Aging
Animals
Cell
Cells
Development
Division
Embryonic
Endothelial
Endothelium
Factor
Growth
Human
Humans
Japan
Ligands
Lymphangiogenesis
Lymphatic
Lymphedema
Neovascularization
Pathologic
Physiologic
Placenta
Receptor-1
Receptor-2
Research
Signal
System
Transduction
Tyrosine
Vascular
Vertebrates
cells
cytology
genetics
physiology
physiopathology
response
AgingAnimalsCellCellsDevelopmentDivisionEmbryonicEndothelialEndotheliumFactorGrowthHumanHumansJapanLigandsLymphangiogenesisLymphaticLymphedemaNeovascularizationPathologicPhysiologicPlacentaReceptor-1Receptor-2ResearchSignalSystemTransductionTyrosineVascularVertebratescellscytologygeneticsphysiologyphysiopathologyresponse
(0)
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1Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients
S. Nadar, A. Blann, and G. Lip. Am.J.Hypertens., 19 (9): 970-977 (2006)
15 years ago by @kanefendt
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A
Activation
Aged
Aggregation
Angiopoietin-1
Aspirin
Biological
Blood
Case-Control
Count
Cyclooxygenase
Endothelial
England
Factor
Female
Follow-Up
Growth
Humans
Hypertension
Immunoassay
Inhibitors
Longitudinal
Male
Markers
Middle
Outcome
P-Selectin
Platelet
Platelets
Pressure
Research
Studies
Thrombosis
Treatment
Vascular
blood
drug
effects
metabolism
methods
pharmacology
physiopathology
therapeutic
therapy
use
AActivationAgedAggregationAngiopoietin-1AspirinBiologicalBloodCase-ControlCountCyclooxygenaseEndothelialEnglandFactorFemaleFollow-UpGrowthHumansHypertensionImmunoassayInhibitorsLongitudinalMaleMarkersMiddleOutcomeP-SelectinPlateletPlateletsPressureResearchStudiesThrombosisTreatmentVascularblooddrugeffectsmetabolismmethodspharmacologyphysiopathologytherapeutictherapyuse
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1Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
M. Shibuya. J Biochem.Mol.Biol., 39 (5): 469-478 (2006)
15 years ago by @kanefendt
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A
Animals
Atherosclerosis
Cells
Chemistry
Development
Dna
Embryonic
Endothelial
Factor
Female
Growth
Human
Humans
Inflammation
Japan
Metastasis
Mice
Neoplasm
Neoplasms
Neovascularization
Pathologic
Physiologic
Pre-Eclampsia
Pregnancy
Proteins
Receptor-1
Receptor-2
Research
Signal
Transduction
Tyrosine
Vascular
Viral
blood
cells
genetics
metabolism
physiology
physiopathology
protein
response
supply
therapy
AAnimalsAtherosclerosisCellsChemistryDevelopmentDnaEmbryonicEndothelialFactorFemaleGrowthHumanHumansInflammationJapanMetastasisMiceNeoplasmNeoplasmsNeovascularizationPathologicPhysiologicPre-EclampsiaPregnancyProteinsReceptor-1Receptor-2ResearchSignalTransductionTyrosineVascularViralbloodcellsgeneticsmetabolismphysiologyphysiopathologyproteinresponsesupplytherapy
(0)
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1Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
H. Verheul, and H. Pinedo. Nat.Rev.Cancer, 7 (6): 475-485 (2007)
15 years ago by @kanefendt
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&
A
Administration
Agents
Angiogenesis
Antineoplastic
Biological
Blood
Clinical
Coagulation
Drug
Endothelial
Factor
Function
Growth
Humans
Hypertension
Inhibitors
Left
Models
Neoplasm
Platelets
Research
Resistance
Schedule
Signal
Thrombosis
Topic
Transduction
Trials
Vascular
Ventricular
administration
adverse
antagonists
as
chemically
dosage
drug
effects
etiology
induced
inhibitors
physiology
toxicity
&AAdministrationAgentsAngiogenesisAntineoplasticBiologicalBloodClinicalCoagulationDrugEndothelialFactorFunctionGrowthHumansHypertensionInhibitorsLeftModelsNeoplasmPlateletsResearchResistanceScheduleSignalThrombosisTopicTransductionTrialsVascularVentricularadministrationadverseantagonistsaschemicallydosagedrugeffectsetiologyinducedinhibitorsphysiologytoxicity
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1The role of the VEGF-C/VEGFR-3 axis in cancer progression
J. Su, C. Yen, P. Chen, S. Chuang, C. Hong, I. Kuo, H. Chen, M. Hung, and M. Kuo. Br.J.Cancer, 96 (4): 541-545 (2007)
15 years ago by @kanefendt
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C
Cells
Disease
Endothelial
Factor
Growth
Human
Humans
Leukemia
Lymphangiogenesis
Lymphatic
Neoplasms
Progression
Receptor-3
Research
Vascular
Vessels
cells
metabolism
pathology
physiopathology
CCellsDiseaseEndothelialFactorGrowthHumanHumansLeukemiaLymphangiogenesisLymphaticNeoplasmsProgressionReceptor-3ResearchVascularVesselscellsmetabolismpathologyphysiopathology
(0)
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1Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis
A. Debrah, S. Mand, S. Specht, Y. Marfo-Debrekyei, L. Batsa, K. Pfarr, J. Larbi, B. Lawson, M. Taylor, O. Adjei and 1 other author(s). PLoS.Pathog., 2 (9): e92 (2006)
15 years ago by @kanefendt
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&
Adult
Aged
Animals
C
Data
Doxycycline
Elephantiasis
Endothelial
Factor
Female
Filarial
Filaricides
Growth
Humans
Hydrocele
Intercellular
Lymphatic
Lymphedema
Male
Microfilaria
Middle
Molecular
Outcome
Parasitemia
Peptides
Plasma
Proteins
Receptor-3
Research
Sequence
Signaling
System
Testicular
Testis
Treatment
Vascular
Vessels
Wolbachia
and
antagonists
blood
drug
effects
immunology
inhibitors
isolation
parasitology
pathology
physiology
protein
purification
therapeutic
therapy
ultrasonography
use
&AdultAgedAnimalsCDataDoxycyclineElephantiasisEndothelialFactorFemaleFilarialFilaricidesGrowthHumansHydroceleIntercellularLymphaticLymphedemaMaleMicrofilariaMiddleMolecularOutcomeParasitemiaPeptidesPlasmaProteinsReceptor-3ResearchSequenceSignalingSystemTesticularTestisTreatmentVascularVesselsWolbachiaandantagonistsblooddrugeffectsimmunologyinhibitorsisolationparasitologypathologyphysiologyproteinpurificationtherapeutictherapyultrasonographyuse
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1Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome
M. Cuadrado, P. Buendia, F. Velasco, M. Aguirre, N. Barbarroja, L. Torres, M. Khamashta, and C. Lopez-Pedrera. J.Thromb.Haemost., 4 (11): 2461-2469 (2006)
15 years ago by @kanefendt
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&
A
Adolescent
Adult
Aged
Antibodies
Antiphospholipid
Cells
Cultured
Endothelial
Enzyme
Expression
Factor
Female
Gene
Growth
Human
Humans
Imidazoles
Inhibitors
Kinase
Kinases
MAP
Male
Middle
Mitogen-Activated
Monocytes
Phenotype
Protein
Pyridines
Receptor-1
Regulation
Research
Signaling
Syndrome
System
Thromboplastin
Thrombosis
Tyrosine
Vascular
antagonists
biosynthesis
cells
drug
effects
inhibitors
metabolism
p38
pathology
pharmacology
protein
&AAdolescentAdultAgedAntibodiesAntiphospholipidCellsCulturedEndothelialEnzymeExpressionFactorFemaleGeneGrowthHumanHumansImidazolesInhibitorsKinaseKinasesMAPMaleMiddleMitogen-ActivatedMonocytesPhenotypeProteinPyridinesReceptor-1RegulationResearchSignalingSyndromeSystemThromboplastinThrombosisTyrosineVascularantagonistsbiosynthesiscellsdrugeffectsinhibitorsmetabolismp38pathologypharmacologyprotein
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1A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
F. Wu, M. Stefanini, G. Mac, and A. Popel. PLoS.One., 4 (4): e5108 (2009)
15 years ago by @kanefendt
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A
Binding
Biological
Biology
Capillaries
Dimerization
Endothelial
Factor
Growth
Human
Humans
Ligands
Lymphatic
Models
Muscle
Plasma
Receptor-1
Research
Skeletal
States
Systems
Tyrosine
United
Vascular
Vessels
metabolism
physiology
protein
therapy
ultrastructure
ABindingBiologicalBiologyCapillariesDimerizationEndothelialFactorGrowthHumanHumansLigandsLymphaticModelsMusclePlasmaReceptor-1ResearchSkeletalStatesSystemsTyrosineUnitedVascularVesselsmetabolismphysiologyproteintherapyultrastructure
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1Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells
N. Rahimi, T. Golde, and R. Meyer. Cancer Res., 69 (6): 2607-2614 (2009)
15 years ago by @kanefendt
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Amyloid
B-Cell
C
Cell
Cells
Cytoplasm
Diffuse
Endothelial
Factor
Growth
Humans
Hypertension
Kinase
Large
Ligands
Lymphoma
Membrane
Necrosis
Phosphorylation
Precursor
Protein
Receptor-1
Research
Secretases
Signal
Structure
Tertiary
Transduction
Tyrosine
Vascular
biosynthesis
cells
enzymology
metabolism
pathology
protein
AmyloidB-CellCCellCellsCytoplasmDiffuseEndothelialFactorGrowthHumansHypertensionKinaseLargeLigandsLymphomaMembraneNecrosisPhosphorylationPrecursorProteinReceptor-1ResearchSecretasesSignalStructureTertiaryTransductionTyrosineVascularbiosynthesiscellsenzymologymetabolismpathologyprotein
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