%0 Journal Article %1 duxbury2019hostpathogen %A Duxbury, Elizabeth ML %A Day, Jonathan P %A Vespasiani, Davide Maria %A Thüringer, Yannik %A Tolosana, Ignacio %A Smith, Sophia CL %A Tagliaferri, Lucia %A Kamacioglu, Altug %A Lindsley, Imogen %A Love, Luca %A Unckless, Robert L %A Jiggins, Francis M %A Longdon, Ben %D 2019 %I eLife Sciences Publications, Ltd %J eLife %K Drosophila coevolution experimental_evolution host-pathogen vertical_transmission %R 10.7554/elife.46440 %T Host-pathogen coevolution increases genetic variation in susceptibility to infection %U https://doi.org/10.7554%2Felife.46440 %V 8 %X It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations.

@article{duxbury2019hostpathogen, abstract = {It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations.}, added-at = {2020-10-05T20:48:37.000+0200}, author = {Duxbury, Elizabeth ML and Day, Jonathan P and Vespasiani, Davide Maria and Thüringer, Yannik and Tolosana, Ignacio and Smith, Sophia CL and Tagliaferri, Lucia and Kamacioglu, Altug and Lindsley, Imogen and Love, Luca and Unckless, Robert L and Jiggins, Francis M and Longdon, Ben}, biburl = {https://www.bibsonomy.org/bibtex/2b08699d6925e8c4738f987dec647236e/peter.ralph}, doi = {10.7554/elife.46440}, interhash = {e1b6e7e427dee13e84d7bd157cfcd124}, intrahash = {b08699d6925e8c4738f987dec647236e}, journal = {{eLife}}, keywords = {Drosophila coevolution experimental_evolution host-pathogen vertical_transmission}, month = apr, publisher = {{eLife} Sciences Publications, Ltd}, timestamp = {2020-10-05T20:48:37.000+0200}, title = {Host-pathogen coevolution increases genetic variation in susceptibility to infection}, url = {https://doi.org/10.7554%2Felife.46440}, volume = 8, year = 2019 }