%0 Journal Article %1 noauthororeditor %A B., Khafizova D. %D 2023 %J CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE %K genetics thrombophilia, %N 6 %P 659-667 %T Assessment of the Role of Genetic Polymorphism of the Hemostatic System Factors of the F3 Gene in the Development of Thrombophilia in Women of the Uzbek Population %U https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2107/2154 %V 4 %X The article presents the results of molecular genetic studies of the hemostasis gene G/T gene F3 in women with unsuccessful IVF who have thrombophilia in the Uzbek population living. Analysis of molecular genetic studies of the frequency distribution of alleles of the G/T polymorphism of the F3 gene in a sample of women from the main group showed that the functional G allele was determined in 72.7%, and in the group of control individuals without thrombophilia - in 100%, respectively. (χ2=10.65; p<0.001; OR=0.04; 95%CI 0.00 – 0.73). While the mutant allele “T” in the main group was detected in 49 chromosomes (49/180), which accounted for 37.4% of cases. (χ2=10.65; p<0.001; OR=22.96; 95%CI 1.38 – 382.75). Clinical molecular genetic studies indicate that patients with identified non-functional genotypes G/T of the F3 gene are at risk of developing severe thrombophilia, which amounted to 38.8% of cases. (χ2=11.67; p<0.003; OR=19.83; 95% CI1.15 – 341.95). Variants of polymorphisms of hetero-G/T and homozygous genotypes T/T of the F3 gene are significant prognostic criteria for the risk of developing undeveloped pregnancies in women with thrombophilia among women of the Uzbek population.

@article{noauthororeditor, abstract = {The article presents the results of molecular genetic studies of the hemostasis gene G/T gene F3 in women with unsuccessful IVF who have thrombophilia in the Uzbek population living. Analysis of molecular genetic studies of the frequency distribution of alleles of the G/T polymorphism of the F3 gene in a sample of women from the main group showed that the functional G allele was determined in 72.7%, and in the group of control individuals without thrombophilia - in 100%, respectively. (χ2=10.65; p<0.001; OR=0.04; 95%CI 0.00 – 0.73). While the mutant allele “T” in the main group was detected in 49 chromosomes (49/180), which accounted for 37.4% of cases. (χ2=10.65; p<0.001; OR=22.96; 95%CI 1.38 – 382.75). Clinical molecular genetic studies indicate that patients with identified non-functional genotypes G/T of the F3 gene are at risk of developing severe thrombophilia, which amounted to 38.8% of cases. (χ2=11.67; p<0.003; OR=19.83; 95% CI1.15 – 341.95). Variants of polymorphisms of hetero-G/T and homozygous genotypes T/T of the F3 gene are significant prognostic criteria for the risk of developing undeveloped pregnancies in women with thrombophilia among women of the Uzbek population.}, added-at = {2024-02-16T10:45:14.000+0100}, author = {B., Khafizova D.}, biburl = {https://www.bibsonomy.org/bibtex/2214247f27a0fd1e0829228b05c176040/centralasian_20}, interhash = {c24c5dde3e576df4de46bd04d9eaa68b}, intrahash = {214247f27a0fd1e0829228b05c176040}, issn = {2660-4159}, journal = {CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE}, keywords = {genetics thrombophilia,}, language = {english}, month = dec, number = 6, pages = {659-667}, timestamp = {2024-02-16T10:45:14.000+0100}, title = {Assessment of the Role of Genetic Polymorphism of the Hemostatic System Factors of the F3 Gene in the Development of Thrombophilia in Women of the Uzbek Population}, url = {https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2107/2154}, volume = 4, year = 2023 }