%0 Journal Article %1 Kadhim2010 %A Kadhim, Hazim %A Deltenre, Paul %A Prez, Carine De %A Sebire, Guillaume %D 2010 %J Neurosci Lett %K metabolism/pathology;Female;Humans;Infant;Interleukin-2 metabolism;Male;Neuroimmunomodulation;SuddenInfantDeath immunology/pathology BrainStem %N 2 %P 122--126 %R 10.1016/j.neulet.2010.06.021 %T Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome. %U http://dx.doi.org/10.1016/j.neulet.2010.06.021 %V 480 %X Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.

@article{Kadhim2010, abstract = {Dysfunction in vital brainstem centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear. Cytokines are inter-cellular signaling chemicals. They can interact with neurotransmitters and might thus modify neural and neuroimmune functions. Cytokines could therefore act as neuromodulators. Interleukin (IL)-2 is a major immune-related cytokine. It has not been previously depicted in vital brainstem centers. We detected intense neuronal IL-2 immune-reactivity in the SIDS brainstem, namely in vital neural centers. This IL-2 overexpression might interfere with neurotransmitters in those critical brainstem centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.}, added-at = {2011-05-27T21:22:49.000+0200}, author = {Kadhim, Hazim and Deltenre, Paul and Prez, Carine De and Sebire, Guillaume}, biburl = {https://www.bibsonomy.org/bibtex/27dbf11482baaf0e66f6782e66acdc5cb/crc_chus}, doi = {10.1016/j.neulet.2010.06.021}, institution = {Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles (U.L.B.), Place van Gehuchten 4, 1020 Brussels, Belgium. Hazim.Kadhim@chu-brugmann.be}, interhash = {null}, intrahash = {7dbf11482baaf0e66f6782e66acdc5cb}, journal = {Neurosci Lett}, keywords = {metabolism/pathology;Female;Humans;Infant;Interleukin-2 metabolism;Male;Neuroimmunomodulation;SuddenInfantDeath immunology/pathology BrainStem}, language = {eng}, month = Aug, number = 2, pages = {122--126}, pii = {S0304-3940(10)00754-8}, pmid = {20542085}, pst = {ppublish}, timestamp = {2011-05-27T21:22:49.000+0200}, title = {Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome.}, url = {http://dx.doi.org/10.1016/j.neulet.2010.06.021}, volume = 480, year = 2010 }