Abstract
In the following work, the vibrational spectroscopic characteristics of
artepillin C are reported by means of Fourier transform infrared (FT-IR)
and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and
coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is
an interesting compound due to its pharmacological properties, including
antitumor activity. It is found as the major component of Brazilian
green propolis, a resinous mixture produced by bees to protect their
hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm(-1), assigned to C=C stretching vibrations from
the aromatic ring of artepillin C. From these data, direct visualization
of artepillin C could be assessed by means of CARS microscopy, showing
differences in the film hydration obtained for its neutral and
deprotonated states. Raman-based methods show potential to visualize the
uptake and action of artepillin C in biological systems, triggering its
interaction with biological systems that are needed to understand its
mechanism of action.
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