%0 Journal Article %1 Law2013Systems %A Law, G. Lynn %A Korth, Marcus J. %A Benecke, Arndt G. %A Katze, Michael G. %D 2013 %I Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. %J Nat Rev Micro %K systems-biology virology %N 7 %P 455--466 %R 10.1038/nrmicro3036 %T Systems virology: host-directed approaches to viral pathogenesis and drug targeting %U http://dx.doi.org/10.1038/nrmicro3036 %V 11 %X High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.

@article{Law2013Systems, abstract = {High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Law, G. Lynn and Korth, Marcus J. and Benecke, Arndt G. and Katze, Michael G.}, biburl = {https://www.bibsonomy.org/bibtex/2dd4bcbc0c909dc94472f19196c04676f/karthikraman}, citeulike-article-id = {12416134}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrmicro3036}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrmicro3036}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/23728212}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=23728212}, day = 3, doi = {10.1038/nrmicro3036}, interhash = {4af886b13f3a686b31c76cf9c76938f9}, intrahash = {dd4bcbc0c909dc94472f19196c04676f}, issn = {1740-1534}, journal = {Nat Rev Micro}, keywords = {systems-biology virology}, month = jul, number = 7, pages = {455--466}, pmid = {23728212}, posted-at = {2013-06-14 11:58:25}, priority = {2}, publisher = {Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Systems virology: host-directed approaches to viral pathogenesis and drug targeting}, url = {http://dx.doi.org/10.1038/nrmicro3036}, volume = 11, year = 2013 }