%0 Journal Article %1 Mandrekar2009 %A Mandrekar, Jayawant N %A Mandrekar, Sumithra J %D 2009 %J Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer %K BiomedicalResearch Biostatistics Biostatistics:methods DataCollection DataCollection:statistics&numericaldata DataInterpretation Humans ReproducibilityofResults Statistical %N 12 %P 1447-9 %R 10.1097/JTO.0b013e3181c0a329 %T Biostatistics: a toolkit for exploration, validation, and interpretation of clinical data. %U http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2796575&tool=pmcentrez&rendertype=abstract %V 4 %X Biostatistics plays a key role in all phases of clinical research starting from the design to the monitoring, data collection, data analysis, and interpretation of the results. A clear understanding of the statistical framework as it relates to the study hypothesis, reported results, and interpretation is vital for the scientific integrity of the study and its acceptance in the general medical community. In this brief report, we will put in perspective the general analytical framework for exploring and validating prognostic factors using data from large databases. %@ 1556-1380; 1556-0864

@article{Mandrekar2009, abstract = {Biostatistics plays a key role in all phases of clinical research starting from the design to the monitoring, data collection, data analysis, and interpretation of the results. A clear understanding of the statistical framework as it relates to the study hypothesis, reported results, and interpretation is vital for the scientific integrity of the study and its acceptance in the general medical community. In this brief report, we will put in perspective the general analytical framework for exploring and validating prognostic factors using data from large databases.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Mandrekar, Jayawant N and Mandrekar, Sumithra J}, biburl = {https://www.bibsonomy.org/bibtex/28450c749cb0dbb7226b3260569429398/jepcastel}, city = {Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA. mandrekar.sumithra@mayo.edu}, doi = {10.1097/JTO.0b013e3181c0a329}, interhash = {423a2e4dddb54051f0793ea26196e277}, intrahash = {8450c749cb0dbb7226b3260569429398}, isbn = {1556-1380; 1556-0864}, issn = {1556-1380}, journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer}, keywords = {BiomedicalResearch Biostatistics Biostatistics:methods DataCollection DataCollection:statistics&numericaldata DataInterpretation Humans ReproducibilityofResults Statistical}, month = {12}, note = {6013<m:linebreak></m:linebreak>LR: 20110303; GR: CA-15083/CA/NCI NIH HHS/United States; GR: CA-25224/CA/NCI NIH HHS/United States; GR: P30 CA015083-35/CA/NCI NIH HHS/United States; GR: U10 CA025224-30/CA/NCI NIH HHS/United States; JID: 101274235; NIHMS153835; OID: NLM: NIHMS153835; OID: NLM: PMC2796575; ppublish;}, number = 12, pages = {1447-9}, pmid = {20009908}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Biostatistics: a toolkit for exploration, validation, and interpretation of clinical data.}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2796575&tool=pmcentrez&rendertype=abstract}, volume = 4, year = 2009 }