A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.
%0 Journal Article
%1 wagner2007modularity
%A Wagner, G P
%A Pavlicev, M
%A Cheverud, J M
%D 2007
%J Nat Rev Genet
%K reading_group regulatory_networks review
%N 12
%P 921-931
%R 10.1038/nrg2267
%T The road to modularity
%U https://www.ncbi.nlm.nih.gov/pubmed/18007649
%V 8
%X A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.
@article{wagner2007modularity,
abstract = {A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.},
added-at = {2018-09-28T21:06:50.000+0200},
author = {Wagner, G P and Pavlicev, M and Cheverud, J M},
biburl = {https://www.bibsonomy.org/bibtex/2ff828fad169c97dc2f14a25ec3f027d4/peter.ralph},
doi = {10.1038/nrg2267},
interhash = {283c27944fe28b4606cb75281d81aa34},
intrahash = {ff828fad169c97dc2f14a25ec3f027d4},
journal = {Nat Rev Genet},
keywords = {reading_group regulatory_networks review},
month = dec,
number = 12,
pages = {921-931},
pmid = {18007649},
timestamp = {2018-09-28T21:06:50.000+0200},
title = {The road to modularity},
url = {https://www.ncbi.nlm.nih.gov/pubmed/18007649},
volume = 8,
year = 2007
}