Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.
OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.
%0 Journal Article
%1 Bottcher2006dk
%A Böttcher, J
%A Pfeil, A
%A Rosholm, A
%A Sörös, P
%A Petrovitch, A
%A Schaefer, ML
%A Seidl, BE
%A Malich, A
%A Hansch, A
%A Wolf, G
%A Kaiser, WA
%D 2006
%J Invest Radiol
%K Severity and Adolescent Middle Aged, Rheumatoid/pathology Disease Bone Illness Demineralization, Radiographic 80 neuroscience Densitometry, Joint/pathology Arthritis, Non-U.S. Support, Software Aged Adult Index of Gov't Male AND Linear Image X-Ray/*methods Pathologic/pathology Female Models Nonparametric over Research Humans Enhancement/*methods Statistics, Progression Metacarpophalangeal
%N 1
%P 36-44
%T Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.
%V 41
%X OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.
@article{Bottcher2006dk,
abstract = {OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.},
added-at = {2006-05-30T01:06:19.000+0200},
affiliation = {Institute of Diagnostic and Interventional Radiology; Friedrich-Schiller-University Jena, Germany. joachim.boettcher@med.uni-jena.de},
au = {B{\"o}ttcher, J},
author = {B{\"o}ttcher, J and Pfeil, A and Rosholm, A and S{\"o}r{\"o}s, P and Petrovitch, A and Schaefer, ML and Seidl, BE and Malich, A and Hansch, A and Wolf, G and Kaiser, WA},
biburl = {https://www.bibsonomy.org/bibtex/2f2000f94121d667b4ed4c808556ca645/asterix},
da = {20051215},
date-added = {2006-05-29 18:55:11 -0400},
date-modified = {2006-05-29 18:55:12 -0400},
dcom = {20060323},
description = {neuroscience literature},
edat = {2005/12/16 09:00},
interhash = {e439c1c4371fe7febe6b52e0d0457abc},
intrahash = {f2000f94121d667b4ed4c808556ca645},
issn = {0020-9996},
jid = {0045377},
journal = {Invest Radiol},
keywords = {Severity and Adolescent Middle Aged, Rheumatoid/pathology Disease Bone Illness Demineralization, Radiographic 80 neuroscience Densitometry, Joint/pathology Arthritis, Non-U.S. Support, Software Aged Adult Index of Gov't Male AND Linear Image X-Ray/*methods Pathologic/pathology Female Models Nonparametric over Research Humans Enhancement/*methods Statistics, Progression Metacarpophalangeal},
language = {eng},
mhda = {2006/03/24 09:00},
month = Jan,
number = 1,
own = {NLM},
pages = {36-44},
pmid = {16355038},
pst = {ppublish},
pt = {Journal Article},
pubm = {Print},
so = {Invest Radiol 2006 Jan;41(1):36-44.},
stat = {MEDLINE},
timestamp = {2006-05-30T01:06:19.000+0200},
title = {Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.},
volume = 41,
year = 2006
}