%0 Journal Article %1 Strom2007 %A Strom, Brian L %D 2007 %J Medical care %K Bias(Epidemiology) ConfoundingFactors(Epidemiology) DataCollection DataCollection:methods DrugEvaluation DrugEvaluation:methods DrugEvaluation:statistics&numericaldata Humans Pharmacoepidemiology Postmarketing Postmarketing:methods Postmarketing:statistics&numericaldata ProductSurveillance ResearchDesign RiskManagement RiskManagement:methods RiskManagement:statistics&numericaldata %N 10 Supl 2 %P S13-5 %R 10.1097/MLR.0b013e318041f752 %T Methodologic challenges to studying patient safety and comparative effectiveness. %U http://www.ncbi.nlm.nih.gov/pubmed/17909371 %V 45 %X Studies of patient safety and comparative effectiveness entail unique methodologic challenges. These studies may be susceptible to systematic error, including selection bias, exposure misclassification, and outcome misclassification. They may also be vulnerable to random error, or confounding by a variable such as another drug, a disease, or the drug indication itself. Finally, special logistical issues can arise, including data access problems, difficulties in conveying the need for studies of certain interventions, and obstacles to gaining institutional review board approval. This article provides a conceptual overview of these methodologic issues. %@ 0025-7079; 0025-7079

@article{Strom2007, abstract = {Studies of patient safety and comparative effectiveness entail unique methodologic challenges. These studies may be susceptible to systematic error, including selection bias, exposure misclassification, and outcome misclassification. They may also be vulnerable to random error, or confounding by a variable such as another drug, a disease, or the drug indication itself. Finally, special logistical issues can arise, including data access problems, difficulties in conveying the need for studies of certain interventions, and obstacles to gaining institutional review board approval. This article provides a conceptual overview of these methodologic issues.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Strom, Brian L}, biburl = {https://www.bibsonomy.org/bibtex/2e84d06814ec197f138e99433878f8055/jepcastel}, city = {Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. bstrom@cceb.med.upenn.edu}, doi = {10.1097/MLR.0b013e318041f752}, interhash = {51d4e0b4714ebeb4114c777da97a35af}, intrahash = {e84d06814ec197f138e99433878f8055}, isbn = {0025-7079; 0025-7079}, issn = {0025-7079}, journal = {Medical care}, keywords = {Bias(Epidemiology) ConfoundingFactors(Epidemiology) DataCollection DataCollection:methods DrugEvaluation DrugEvaluation:methods DrugEvaluation:statistics&numericaldata Humans Pharmacoepidemiology Postmarketing Postmarketing:methods Postmarketing:statistics&numericaldata ProductSurveillance ResearchDesign RiskManagement RiskManagement:methods RiskManagement:statistics&numericaldata}, month = {10}, note = {6358<m:linebreak></m:linebreak>GR: HHSA290200500361/PHS HHS/United States; JID: 0230027; ppublish;<m:linebreak></m:linebreak>CER}, number = {10 Supl 2}, pages = {S13-5}, pmid = {17909371}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Methodologic challenges to studying patient safety and comparative effectiveness.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17909371}, volume = 45, year = 2007 }