%0 Journal Article %1 kaoud_hussein_a_2020_4319459 %A A, Kaoud Hussein %A H, Elsaied Ahmed %A A, Khalil Maged %D 2020 %J GSC Advanced Research and Reviews %K Brain Damage %N 1 %P 069-077 %R 10.30574/gscarr.2020.4.1.0060 %T Effect of alpha-cypermethrin on serotonin, nor-epinephrine and brain changes in rats %U https://gsconlinepress.com/journals/gscarr/content/effect-alpha-cypermethrin-serotonin-nor-epinephrine-and-brain-changes-rats %V 4 %X In the present study, brain damages, serotonin and nor-epinephrine activity on rat brain were investigated. A single sub-acute lethal -oral dose of Alpha-Cypermethrin (25 mg kg -1) was given to rat. Blood and brain tissue samples were examined biologically and histopathologically at various times (1, 2, 3, 4 and24 h) after dosing. Results revealed that extracellular serotonin levels % (f mol/mg tissue) in rat ventral hippocampus at 25 mg kg-1 B.W. After 1, 2, 3 and 24 hr. were 105±4, 80 ±7, 80 ±4, 70 ±4, respectively. While extracellular NA levels after 1, 2, 3 and 24 hr. were 300±10, 450 ±14, 400±12, 400±11, respectively. Alpha-cypermethrin acts as nor-epinephrine reuptake inhibitors (NRIs) and serotonin reuptake stimulator in rat brain. The lesions in the brain of the treated groups were gliosis, perineuronal vacuolation, perivascular vacuolation, and neuronal degeneration.

@article{kaoud_hussein_a_2020_4319459, abstract = {In the present study, brain damages, serotonin and nor-epinephrine activity on rat brain were investigated. A single sub-acute lethal -oral dose of Alpha-Cypermethrin (25 mg kg -1) was given to rat. Blood and brain tissue samples were examined biologically and histopathologically at various times (1, 2, 3, 4 and24 h) after dosing. Results revealed that extracellular serotonin levels % (f mol/mg tissue) in rat ventral hippocampus at 25 mg kg-1 B.W. After 1, 2, 3 and 24 hr. were 105±4, 80 ±7, 80 ±4, 70 ±4, respectively. While extracellular NA levels after 1, 2, 3 and 24 hr. were 300±10, 450 ±14, 400±12, 400±11, respectively. Alpha-cypermethrin acts as nor-epinephrine reuptake inhibitors (NRIs) and serotonin reuptake stimulator in rat brain. The lesions in the brain of the treated groups were gliosis, perineuronal vacuolation, perivascular vacuolation, and neuronal degeneration.}, added-at = {2021-01-09T11:55:43.000+0100}, author = {A, Kaoud Hussein and H, Elsaied Ahmed and A, Khalil Maged}, biburl = {https://www.bibsonomy.org/bibtex/2a49e7d3096156e3de09f81bbdecc8d7b/gscarrjournal}, doi = {10.30574/gscarr.2020.4.1.0060}, interhash = {5a4959d737d5848559769f973381d2d5}, intrahash = {a49e7d3096156e3de09f81bbdecc8d7b}, issn = {2582-4597}, journal = {GSC Advanced Research and Reviews}, keywords = {Brain Damage}, month = jul, number = 1, pages = {069-077}, timestamp = {2021-01-09T11:55:43.000+0100}, title = {Effect of alpha-cypermethrin on serotonin, nor-epinephrine and brain changes in rats}, url = {https://gsconlinepress.com/journals/gscarr/content/effect-alpha-cypermethrin-serotonin-nor-epinephrine-and-brain-changes-rats}, volume = 4, year = 2020 }