Analysis of 182 Neisseria meningitidis strains isolated over the past 30 years in Japan by serogroup typing and multilocus sequence typing (MLST) was performed. The serogroups of the 182 Japanese isolates were B (103 isolates), Y (39), W135 (1) and non-groupable (39). By MLST analysis, 65 different sequence types (ST) were identified, 42 of which were not found in the MLST database as of January 2004 and seemed to be unique to Japan. Statistical analysis of the MLST results revealed that, although the Japanese isolates seemed to be genetically divergent, they were classified into six major clonal complexes and other minor complexes. Among these isolates, well-documented ST complexes found worldwide were present, such as ST-23 complex (49 isolates), ST-44 complex (41 isolates) and ST-32 complex (8 isolates). On the other hand, a new clonal complex designated ST-2046 complex (28 isolates), which has not been identified in other countries, was also found, suggesting that this clone was indigenous to Japan. Taken together, it was speculated that meningococcal isolates in Japan comprised heterogeneous clones, which were derived both from clones identified in other countries and clones unique to Japan.
%0 Journal Article
%1 takahashi_characterization_2004
%A Takahashi, Hideyuki
%A Kuroki, Toshiro
%A Watanabe, Yuko
%A Tanaka, Hiroshi
%A Inouye, Hiroo
%A Yamai, Shiro
%A Watanabe, Haruo
%D 2004
%J Journal of Medical Microbiology
%K Alcohol Alleles, Analysis, Bacterial Bacterial, Dehydrogenases Epidemiology, Genes, Genetic Homology, Humans, Infections, Japan, Meningococcal Molecular, Neisseria Phylogeny, Sequence Serotyping, Sugar Techniques, Typing Variation, meningitidis, {DNA,}
%N Pt 7
%P 657--662
%T Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence typing
%U http://www.ncbi.nlm.nih.gov/pubmed/15184538
%V 53
%X Analysis of 182 Neisseria meningitidis strains isolated over the past 30 years in Japan by serogroup typing and multilocus sequence typing (MLST) was performed. The serogroups of the 182 Japanese isolates were B (103 isolates), Y (39), W135 (1) and non-groupable (39). By MLST analysis, 65 different sequence types (ST) were identified, 42 of which were not found in the MLST database as of January 2004 and seemed to be unique to Japan. Statistical analysis of the MLST results revealed that, although the Japanese isolates seemed to be genetically divergent, they were classified into six major clonal complexes and other minor complexes. Among these isolates, well-documented ST complexes found worldwide were present, such as ST-23 complex (49 isolates), ST-44 complex (41 isolates) and ST-32 complex (8 isolates). On the other hand, a new clonal complex designated ST-2046 complex (28 isolates), which has not been identified in other countries, was also found, suggesting that this clone was indigenous to Japan. Taken together, it was speculated that meningococcal isolates in Japan comprised heterogeneous clones, which were derived both from clones identified in other countries and clones unique to Japan.
@article{takahashi_characterization_2004,
abstract = {Analysis of 182 Neisseria meningitidis strains isolated over the past 30 years in Japan by serogroup typing and multilocus sequence typing {(MLST)} was performed. The serogroups of the 182 Japanese isolates were B (103 isolates), Y (39), W135 (1) and non-groupable (39). By {MLST} analysis, 65 different sequence types {(ST)} were identified, 42 of which were not found in the {MLST} database as of January 2004 and seemed to be unique to Japan. Statistical analysis of the {MLST} results revealed that, although the Japanese isolates seemed to be genetically divergent, they were classified into six major clonal complexes and other minor complexes. Among these isolates, well-documented {ST} complexes found worldwide were present, such as {ST-23} complex (49 isolates), {ST-44} complex (41 isolates) and {ST-32} complex (8 isolates). On the other hand, a new clonal complex designated {ST-2046} complex (28 isolates), which has not been identified in other countries, was also found, suggesting that this clone was indigenous to Japan. Taken together, it was speculated that meningococcal isolates in Japan comprised heterogeneous clones, which were derived both from clones identified in other countries and clones unique to Japan.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Takahashi, Hideyuki and Kuroki, Toshiro and Watanabe, Yuko and Tanaka, Hiroshi and Inouye, Hiroo and Yamai, Shiro and Watanabe, Haruo},
biburl = {https://www.bibsonomy.org/bibtex/2960e7cf91c20c051b41fa554dfc90210/jelias},
interhash = {238ffc89627be20ef3df81c4a2f1b3f2},
intrahash = {960e7cf91c20c051b41fa554dfc90210},
issn = {0022-2615},
journal = {Journal of Medical Microbiology},
keywords = {Alcohol Alleles, Analysis, Bacterial Bacterial, Dehydrogenases Epidemiology, Genes, Genetic Homology, Humans, Infections, Japan, Meningococcal Molecular, Neisseria Phylogeny, Sequence Serotyping, Sugar Techniques, Typing Variation, meningitidis, {DNA,}},
month = jul,
note = {{PMID:} 15184538},
number = {Pt 7},
pages = {657--662},
timestamp = {2011-03-11T10:06:46.000+0100},
title = {Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence typing},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15184538},
volume = 53,
year = 2004
}