The "Virtual Cell" provides a general system for testing cell biological
mechanisms and creates a framework for encapsulating the burgeoning
knowledge base comprising the distribution and dynamics of intracellular
biochemical processes. It approaches the problem by associating biochemical
and electrophysiological data describing individual reactions with
experimental microscopic image data describing their subcellular
localizations. Individual processes are collected within a physical
and computational infrastructure that accommodates any molecular
mechanism expressible as rate equations or membrane fluxes. An illustration
of the method is provided by a dynamic simulation of IP3-mediated
Ca$^2+$ release from endoplasmic reticulum in a neuronal cell.
The results can be directly compared to experimental observations
and provide insight into the role of experimentally inaccessible
components of the overall mechanism.
%0 Journal Article
%1 Scha_1997_1135
%A Schaff, J.
%A Fink, C. C.
%A Slepchenko, B.
%A Carson, J. H.
%A Loew, L. M.
%D 1997
%J Biophys. J.
%K 9284281 Animals, Biological, Calcium, Cell Cells, Computer Electrostatics, Gov't, Models, Neurons, P.H.S., Physiology, Research Simulation, Support, U.S.
%N 3
%P 1135--1146
%T A general computational framework for modeling cellular structure
and function.
%V 73
%X The "Virtual Cell" provides a general system for testing cell biological
mechanisms and creates a framework for encapsulating the burgeoning
knowledge base comprising the distribution and dynamics of intracellular
biochemical processes. It approaches the problem by associating biochemical
and electrophysiological data describing individual reactions with
experimental microscopic image data describing their subcellular
localizations. Individual processes are collected within a physical
and computational infrastructure that accommodates any molecular
mechanism expressible as rate equations or membrane fluxes. An illustration
of the method is provided by a dynamic simulation of IP3-mediated
Ca$^2+$ release from endoplasmic reticulum in a neuronal cell.
The results can be directly compared to experimental observations
and provide insight into the role of experimentally inaccessible
components of the overall mechanism.
@article{Scha_1997_1135,
abstract = {The "Virtual Cell" provides a general system for testing cell biological
mechanisms and creates a framework for encapsulating the burgeoning
knowledge base comprising the distribution and dynamics of intracellular
biochemical processes. It approaches the problem by associating biochemical
and electrophysiological data describing individual reactions with
experimental microscopic image data describing their subcellular
localizations. Individual processes are collected within a physical
and computational infrastructure that accommodates any molecular
mechanism expressible as rate equations or membrane fluxes. An illustration
of the method is provided by a dynamic simulation of IP3-mediated
{C}a$^{2+}$ release from endoplasmic reticulum in a neuronal cell.
The results can be directly compared to experimental observations
and provide insight into the role of experimentally inaccessible
components of the overall mechanism.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Schaff, J. and Fink, C. C. and Slepchenko, B. and Carson, J. H. and Loew, L. M.},
biburl = {https://www.bibsonomy.org/bibtex/27435ee3a55a9de725b45008d10a3ce17/hake},
description = {The whole bibliography file I use.},
file = {Scha_1997_1135.pdf:Scha_1997_1135.pdf:PDF},
interhash = {e7787c4b4bbe2cab8a9fdb5dcbab7236},
intrahash = {7435ee3a55a9de725b45008d10a3ce17},
journal = {Biophys. J.},
keywords = {9284281 Animals, Biological, Calcium, Cell Cells, Computer Electrostatics, Gov't, Models, Neurons, P.H.S., Physiology, Research Simulation, Support, U.S.},
month = Sep,
number = 3,
pages = {1135--1146},
pmid = {9284281},
timestamp = {2009-06-03T11:21:28.000+0200},
title = {A general computational framework for modeling cellular structure
and function.},
volume = 73,
year = 1997
}