%0 Journal Article %1 noauthororeditor %A Bekele, Yonas %A Lakshmikanth, Tadepally %A Chen, Yang %A Mikes, Jaromir %A Nasi, Aikaterini %A Petkov, Stefan %A Hejdeman, Bo %A Brodin, Petter %A Chiodi, Francesca %D 2019 %J JCI insight %K HIV %N 3 %R 10.1172/jci.insight.125442 %T Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation. %V 4 %X Recent guidelines recommend antiretroviral therapy (ART) to be administered as early as possible during HIV-1 infection. Few studies addressed the immunological benefit of commencing ART during the acute phase of infection. We used mass cytometry to characterize blood CD4+ T cells from HIV-1-infected patients who initiated ART during acute or chronic phase of infection. Using this method, we analyzed a large number of markers on millions of individual immune cells. The results revealed that CD4+ T cell clusters with high expression of CD27, CD28, CD127, and CD44, whose function involves T cell migration to inflamed tissues and survival, are more abundant in healthy controls and patients initiating ART during the acute phase; on the contrary, CD4+ T cell clusters in patients initiating ART during the chronic phase had reduced expression of these markers. The results are suggestive of a better preserved immune function in HIV-1-infected patients initiating ART during acute infection.

@article{noauthororeditor, abstract = {Recent guidelines recommend antiretroviral therapy (ART) to be administered as early as possible during HIV-1 infection. Few studies addressed the immunological benefit of commencing ART during the acute phase of infection. We used mass cytometry to characterize blood CD4+ T cells from HIV-1-infected patients who initiated ART during acute or chronic phase of infection. Using this method, we analyzed a large number of markers on millions of individual immune cells. The results revealed that CD4+ T cell clusters with high expression of CD27, CD28, CD127, and CD44, whose function involves T cell migration to inflamed tissues and survival, are more abundant in healthy controls and patients initiating ART during the acute phase; on the contrary, CD4+ T cell clusters in patients initiating ART during the chronic phase had reduced expression of these markers. The results are suggestive of a better preserved immune function in HIV-1-infected patients initiating ART during acute infection.}, added-at = {2020-04-02T19:07:19.000+0200}, author = {Bekele, Yonas and Lakshmikanth, Tadepally and Chen, Yang and Mikes, Jaromir and Nasi, Aikaterini and Petkov, Stefan and Hejdeman, Bo and Brodin, Petter and Chiodi, Francesca}, biburl = {https://www.bibsonomy.org/bibtex/25a2f809501e10eb65bd14d49fc81b18b/lkanth}, description = {Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1–infected patients according to antiretroviral therapy initiation}, doi = {10.1172/jci.insight.125442}, interhash = {8a6713b8e90fd02bf25955203229cc54}, intrahash = {5a2f809501e10eb65bd14d49fc81b18b}, issn = {2379-3708}, journal = {JCI insight}, keywords = {HIV}, month = {February}, number = 3, timestamp = {2020-04-02T19:07:19.000+0200}, title = {Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.}, volume = 4, year = 2019 }