%0 Journal Article %1 Topp1997b %A Topp, M. %A Langhoff-Roos, J. %A Uldall, P. %D 1997 %J Acta Obstet Gynecol Scand %K Adult; Analysis of Variance; Apgar Score; Cerebral Palsy; Cesarean Section; Denmark; Female; Humans; Infant, Newborn; Premature; Small for Gestational Age; Predictive Value Tests; Pregnancy; Pregnancy Complications; Risk Factors %N 9 %P 843--848 %T Preterm birth and cerebral palsy. Predictive value of pregnancy complications, mode of delivery, and Apgar scores. %V 76 %X BACKGROUND: Preterm infants are at 8 times higher risk than term infants for pre- and perinatal brain damage, resulting in cerebral palsy. In this paper we have analysed the influence of prenatal and birth-related risk factors on cerebral palsy in preterm infants. METHODS: In a register-based study, 175 preterm singleton infants with cerebral palsy, born in 1982-86, were compared with 687 controls matched by gestational age and year of birth. RESULTS: Statistically significant higher rates in cases were found in parity > or = 3 (22\% vs. 16\%, p < 0.05), Cesarean section (67\% vs. 56\%, p < 0.01), and low Apgar scores at 1 minute (45\% vs. 36\%, p < 0.05). By multivariate analyses, two variables remained statistically significant: parity > or = 3 (adjusted OR = 1.53 (95\% CI 1.00-2.34), p < 0.05) and Cesarean section (adjusted OR = 1.57 (95\% CI 1.07-2.32), p < 0.05). CONCLUSIONS: Pregnancy complications preceding preterm birth did not imply a higher risk of cerebral palsy. Delivery by Cesarean section was a prognostic factor for developing cerebral palsy, and the predictive value of Apgar scores was highly limited.

@article{Topp1997b, abstract = {BACKGROUND: Preterm infants are at 8 times higher risk than term infants for pre- and perinatal brain damage, resulting in cerebral palsy. In this paper we have analysed the influence of prenatal and birth-related risk factors on cerebral palsy in preterm infants. METHODS: In a register-based study, 175 preterm singleton infants with cerebral palsy, born in 1982-86, were compared with 687 controls matched by gestational age and year of birth. RESULTS: Statistically significant higher rates in cases were found in parity > or = 3 (22\% vs. 16\%, p < 0.05), Cesarean section (67\% vs. 56\%, p < 0.01), and low Apgar scores at 1 minute (45\% vs. 36\%, p < 0.05). By multivariate analyses, two variables remained statistically significant: parity > or = 3 (adjusted OR = 1.53 (95\% CI 1.00-2.34), p < 0.05) and Cesarean section (adjusted OR = 1.57 (95\% CI 1.07-2.32), p < 0.05). CONCLUSIONS: Pregnancy complications preceding preterm birth did not imply a higher risk of cerebral palsy. Delivery by Cesarean section was a prognostic factor for developing cerebral palsy, and the predictive value of Apgar scores was highly limited.}, added-at = {2014-07-19T21:43:34.000+0200}, author = {Topp, M. and Langhoff-Roos, J. and Uldall, P.}, biburl = {https://www.bibsonomy.org/bibtex/203e10cebdb85a88ee13d9f718b6996e9/ar0berts}, groups = {public}, interhash = {2df5264a4d9f7f9b58206e089d40ca1e}, intrahash = {03e10cebdb85a88ee13d9f718b6996e9}, journal = {Acta Obstet Gynecol Scand}, keywords = {Adult; Analysis of Variance; Apgar Score; Cerebral Palsy; Cesarean Section; Denmark; Female; Humans; Infant, Newborn; Premature; Small for Gestational Age; Predictive Value Tests; Pregnancy; Pregnancy Complications; Risk Factors}, month = Oct, number = 9, pages = {843--848}, pmid = {9351410}, timestamp = {2014-07-19T21:48:53.000+0200}, title = {Preterm birth and cerebral palsy. Predictive value of pregnancy complications, mode of delivery, and Apgar scores.}, username = {ar0berts}, volume = 76, year = 1997 }