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Commercial drivers play a vital role in the US economy as they oversee the country’s roadways. However, with great responsibility comes the need for stringent safety measures, especially concerning drug and alcohol use. The U.S. Department of Transportation (DOT) spearheads efforts to ensure that our roads remain safe by enforcing rigorous drug and alcohol testing regulations for commercial drivers. In 2020, alcohol-impaired driving was responsible for 30% of all traffic-related deaths in the US, highlighting the critical need for such programs. With over 1.3 million commercial truck drivers employed across the nation, the DOT’s regulations are vital in preventing accidents and saving lives. It highlights the crucial role of DOT’s drug and alcohol programs in preventing impaired driving and ensuring road safety.