%0 Journal Article %1 sivakumaran_gobinath_2024_10615010 %A Gobinath, Sivakumaran %A Rajendra, Sittampalam %A Theepan, Jathavani Mariyo Maznet %A Gobishangar, Sreekanthan %A Vaishnavi, Sakthivel %A Hamsavakini, Nadarasa %A Shathana, Paramanathan %D 2024 %J GSC Advanced Research and Reviews %K Invasive breast cancer %N 2 %P 157–161 %R 10.30574/gscarr.2023.17.2.0424 %T An institutional analysis of the correlation between KI 67 index and other prognostic markers in invasive breast cancer in northern province, Sri Lanka %U https://gsconlinepress.com/journals/gscarr/content/institutional-analysis-correlation-between-ki-67-index-and-other-prognostic-markers-invasive %V 17 %X Introduction: Breast cancer is the commonest cancer among females in Sri Lanka. The markers that define the treatment recommendations are Estrogen receptors (ER) status, Progesterone receptor (PR) status, HER-2 neu and Ki-67 proliferative index. Methodology: This is a retrospective study performed on the pathological specimens of invasive ductal carcinoma at Teaching Hospital Jaffna from January 2020 to July 2022. Ki-67 index above 20 was considered high and below 20 as low. The correlation between Ki-67 and other prognostic markers was analyzed as categorical variables using chi-square test. Results: 143 specimens were analyzed, of which 101 were core biopsies and 42 were mastectomy/ WLE specimens. ER, PR and HER2/neu positivity were noted in 100 (69.9%), 85 (59.4%) and 41(28.7%) cases, respectively. Nottingham tumour grade 1,2 and 3 was noted in 16 (11.2%), 74 (51.7%) and 38 (26.6%) cases, respectively. The mean Ki-67 index was 40.21 %. High Ki-67 index was noted in 107(74.8%) and low in 36(25.2%) cases. A significant correlation was noted between ER, PR positivity and Ki-67 index (p=0.02, 0.01). The correlation between HER2/neu positivity and Ki-67 was insignificant (p=0.06). A significant correlation was found between the Ki-67 index and tumour grade (p=0.01). Conclusion: This study showed that high Ki-67 expression is associated with high tumour grade, ER/PR positivity and HER2/neu negativity. Varying results with the published literature reveal geographical variations and warrant large-scale analysis with a bigger sample size.

@article{sivakumaran_gobinath_2024_10615010, abstract = {Introduction: Breast cancer is the commonest cancer among females in Sri Lanka. The markers that define the treatment recommendations are Estrogen receptors (ER) status, Progesterone receptor (PR) status, HER-2 neu and Ki-67 proliferative index. Methodology: This is a retrospective study performed on the pathological specimens of invasive ductal carcinoma at Teaching Hospital Jaffna from January 2020 to July 2022. Ki-67 index above 20 was considered high and below 20 as low. The correlation between Ki-67 and other prognostic markers was analyzed as categorical variables using chi-square test. Results: 143 specimens were analyzed, of which 101 were core biopsies and 42 were mastectomy/ WLE specimens. ER, PR and HER2/neu positivity were noted in 100 (69.9%), 85 (59.4%) and 41(28.7%) cases, respectively. Nottingham tumour grade 1,2 and 3 was noted in 16 (11.2%), 74 (51.7%) and 38 (26.6%) cases, respectively. The mean Ki-67 index was 40.21 %. High Ki-67 index was noted in 107(74.8%) and low in 36(25.2%) cases. A significant correlation was noted between ER, PR positivity and Ki-67 index (p=0.02, 0.01). The correlation between HER2/neu positivity and Ki-67 was insignificant (p=0.06). A significant correlation was found between the Ki-67 index and tumour grade (p=0.01). Conclusion: This study showed that high Ki-67 expression is associated with high tumour grade, ER/PR positivity and HER2/neu negativity. Varying results with the published literature reveal geographical variations and warrant large-scale analysis with a bigger sample size.}, added-at = {2024-03-14T11:49:18.000+0100}, author = {Gobinath, Sivakumaran and Rajendra, Sittampalam and Theepan, Jathavani Mariyo Maznet and Gobishangar, Sreekanthan and Vaishnavi, Sakthivel and Hamsavakini, Nadarasa and Shathana, Paramanathan}, biburl = {https://www.bibsonomy.org/bibtex/20daa86ac6346bbebf58e5e0e644f020b/gscarrjournal}, doi = {10.30574/gscarr.2023.17.2.0424}, interhash = {3129e109efbf4f786ea56e761725fee1}, intrahash = {0daa86ac6346bbebf58e5e0e644f020b}, issn = {2582-4597}, journal = {GSC Advanced Research and Reviews}, keywords = {Invasive breast cancer}, month = feb, number = 2, pages = {157–161}, timestamp = {2024-03-14T11:49:18.000+0100}, title = {An institutional analysis of the correlation between KI 67 index and other prognostic markers in invasive breast cancer in northern province, Sri Lanka}, url = {https://gsconlinepress.com/journals/gscarr/content/institutional-analysis-correlation-between-ki-67-index-and-other-prognostic-markers-invasive}, volume = 17, year = 2024 }