AIM: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. RESULTS: Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. CONCLUSION: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.
%0 Journal Article
%1 Scheinberg2006
%A Scheinberg, Adam
%A Hall, Kate
%A Lam, Lawrence T
%A O'Flaherty, Stephen
%D 2006
%J J Paediatr Child Health
%K Baclofen; Cerebral Palsy; Child; Child, Preschool; Double-Blind Method; Humans; Muscle Spasticity; New Zealand; Pilot Projects; Placebos
%N 11
%P 715--720
%R 10.1111/j.1440-1754.2006.00957.x
%T Oral baclofen in children with cerebral palsy: a double-blind cross-over pilot study.
%U http://dx.doi.org/10.1111/j.1440-1754.2006.00957.x
%V 42
%X AIM: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. RESULTS: Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. CONCLUSION: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.
@article{Scheinberg2006,
abstract = {AIM: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. RESULTS: Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. CONCLUSION: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.},
added-at = {2014-07-19T21:14:31.000+0200},
author = {Scheinberg, Adam and Hall, Kate and Lam, Lawrence T and O'Flaherty, Stephen},
biburl = {https://www.bibsonomy.org/bibtex/2eac7d02d87e8f7106555bf4f3aa9a42a/ar0berts},
doi = {10.1111/j.1440-1754.2006.00957.x},
groups = {public},
interhash = {92e93de1e610f712551ea97a2750ada6},
intrahash = {eac7d02d87e8f7106555bf4f3aa9a42a},
journal = {J Paediatr Child Health},
keywords = {Baclofen; Cerebral Palsy; Child; Child, Preschool; Double-Blind Method; Humans; Muscle Spasticity; New Zealand; Pilot Projects; Placebos},
month = Nov,
number = 11,
pages = {715--720},
pii = {JPC957},
pmid = {17044900},
timestamp = {2014-07-19T21:14:31.000+0200},
title = {Oral baclofen in children with cerebral palsy: a double-blind cross-over pilot study.},
url = {http://dx.doi.org/10.1111/j.1440-1754.2006.00957.x},
username = {ar0berts},
volume = 42,
year = 2006
}