AIMS: To determine the effects of birthweight and gestational age on the risk of cerebral palsy for multiple and singleton births. METHODS: Children on the North East Thames Regional Health Authority Interactive Child Health System, born between 1 January 1980 and 31 December 1986, and notified as having cerebral palsy, were included. Cases of postneonatal onset, of known progressive, or non-cerebral pathology and with only mild signs were excluded. Rates and relative risks were calculated using the most complete data, which related to 1985-86, and comprised 102,059 singletons and 2367 twins. Logistic regression was used to examine the associations between being a twin, gestational age, and birthweight. RESULTS: The crude rate per 1000 survivors at 1 year of age was 1.0 in singletons and 7.4 in twins. The relative risk was greatest in twins weighing more than 2499 g (4.5). However, after adjusting for reduced birthweight of twins it was the relative risk of twins weighing less than 1400 g that was significantly increased. Logistic regression confirmed that lower fetal growth, lower gestational age, and being a twin are all independent risk factors for cerebral palsy. CONCLUSION: The increased risk to twins of cerebral palsy is not entirely explained by their increased risk of prematurity and low birthweight.
%0 Journal Article
%1 Williams1996
%A Williams, K.
%A Hennessy, E.
%A Alberman, E.
%D 1996
%J Arch Dis Child Fetal Neonatal Ed
%K Birth Weight; Cerebral Palsy; Diseases in Twins; England; Gestational Age; Humans; Infant, Newborn; Regression Analysis; Risk Factors
%N 3
%P F178--F182
%T Cerebral palsy: effects of twinning, birthweight, and gestational age.
%V 75
%X AIMS: To determine the effects of birthweight and gestational age on the risk of cerebral palsy for multiple and singleton births. METHODS: Children on the North East Thames Regional Health Authority Interactive Child Health System, born between 1 January 1980 and 31 December 1986, and notified as having cerebral palsy, were included. Cases of postneonatal onset, of known progressive, or non-cerebral pathology and with only mild signs were excluded. Rates and relative risks were calculated using the most complete data, which related to 1985-86, and comprised 102,059 singletons and 2367 twins. Logistic regression was used to examine the associations between being a twin, gestational age, and birthweight. RESULTS: The crude rate per 1000 survivors at 1 year of age was 1.0 in singletons and 7.4 in twins. The relative risk was greatest in twins weighing more than 2499 g (4.5). However, after adjusting for reduced birthweight of twins it was the relative risk of twins weighing less than 1400 g that was significantly increased. Logistic regression confirmed that lower fetal growth, lower gestational age, and being a twin are all independent risk factors for cerebral palsy. CONCLUSION: The increased risk to twins of cerebral palsy is not entirely explained by their increased risk of prematurity and low birthweight.
@article{Williams1996,
abstract = {AIMS: To determine the effects of birthweight and gestational age on the risk of cerebral palsy for multiple and singleton births. METHODS: Children on the North East Thames Regional Health Authority Interactive Child Health System, born between 1 January 1980 and 31 December 1986, and notified as having cerebral palsy, were included. Cases of postneonatal onset, of known progressive, or non-cerebral pathology and with only mild signs were excluded. Rates and relative risks were calculated using the most complete data, which related to 1985-86, and comprised 102,059 singletons and 2367 twins. Logistic regression was used to examine the associations between being a twin, gestational age, and birthweight. RESULTS: The crude rate per 1000 survivors at 1 year of age was 1.0 in singletons and 7.4 in twins. The relative risk was greatest in twins weighing more than 2499 g (4.5). However, after adjusting for reduced birthweight of twins it was the relative risk of twins weighing less than 1400 g that was significantly increased. Logistic regression confirmed that lower fetal growth, lower gestational age, and being a twin are all independent risk factors for cerebral palsy. CONCLUSION: The increased risk to twins of cerebral palsy is not entirely explained by their increased risk of prematurity and low birthweight.},
added-at = {2014-07-19T21:55:03.000+0200},
author = {Williams, K. and Hennessy, E. and Alberman, E.},
biburl = {https://www.bibsonomy.org/bibtex/2e16b74a0b009315ab8cb1ae83aa46619/ar0berts},
groups = {public},
interhash = {b89762e9160c9a93649da540e9bc75d1},
intrahash = {e16b74a0b009315ab8cb1ae83aa46619},
journal = {Arch Dis Child Fetal Neonatal Ed},
keywords = {Birth Weight; Cerebral Palsy; Diseases in Twins; England; Gestational Age; Humans; Infant, Newborn; Regression Analysis; Risk Factors},
month = Nov,
number = 3,
pages = {F178--F182},
pmid = {8976683},
timestamp = {2014-07-19T21:55:03.000+0200},
title = {Cerebral palsy: effects of twinning, birthweight, and gestational age.},
username = {ar0berts},
volume = 75,
year = 1996
}