The nucleophilic aromatic substitution reaction of benzohydrazide derivatives towards 2-chloro-5nitropyrimidine is used as model system to experimentally and theoretically show that intramolecular hydrogen-bond formation operates as a perturbation that elicits a dual response at the reaction center of the transition state (TS) structure, by enhancing the electrophilicity of the pyrimidine moiety and the nucleophilicity of the nitrogen atom of the benzohydrazide fragment. The electronic mechanism can therefore be described as a (non-local) site activation problem.
%0 Journal Article
%1 RN225
%A Gallardo-Fuentes, S.
%A Tapia, R.A.
%A Contreras, R.
%A Campodonico, P.R.
%D 2014
%J Rsc Advances
%K aromatic dqcauchile electrophilicity, functionals, markovnikov model molecules, nucleophilic-substitution, potentials, reactivity, regioselectivity rule, secondary-amines, solvent,
%N 58
%P 30638-30643
%R 10.1039/c4ra04725g
%T Site Activation Effects Promoted by Intramolecular Hydrogen Bond Interactions in Snar Reactions
%U /brokenurl#<Go to ISI>://WOS:000340500300025
%V 4
%X The nucleophilic aromatic substitution reaction of benzohydrazide derivatives towards 2-chloro-5nitropyrimidine is used as model system to experimentally and theoretically show that intramolecular hydrogen-bond formation operates as a perturbation that elicits a dual response at the reaction center of the transition state (TS) structure, by enhancing the electrophilicity of the pyrimidine moiety and the nucleophilicity of the nitrogen atom of the benzohydrazide fragment. The electronic mechanism can therefore be described as a (non-local) site activation problem.
@article{RN225,
abstract = {The nucleophilic aromatic substitution reaction of benzohydrazide derivatives towards 2-chloro-5nitropyrimidine is used as model system to experimentally and theoretically show that intramolecular hydrogen-bond formation operates as a perturbation that elicits a dual response at the reaction center of the transition state (TS) structure, by enhancing the electrophilicity of the pyrimidine moiety and the nucleophilicity of the nitrogen atom of the benzohydrazide fragment. The electronic mechanism can therefore be described as a (non-local) site activation problem.},
added-at = {2019-12-04T03:57:35.000+0100},
author = {Gallardo-Fuentes, S. and Tapia, R.A. and Contreras, R. and Campodonico, P.R.},
biburl = {https://www.bibsonomy.org/bibtex/2ddb77f972dc79f5cce54b799b7db6b21/dqcauchile},
doi = {10.1039/c4ra04725g},
interhash = {42d7b5ce6ccb4e279b8b3833d78d2313},
intrahash = {ddb77f972dc79f5cce54b799b7db6b21},
issn = {2046-2069},
journal = {Rsc Advances},
keywords = {aromatic dqcauchile electrophilicity, functionals, markovnikov model molecules, nucleophilic-substitution, potentials, reactivity, regioselectivity rule, secondary-amines, solvent,},
number = 58,
pages = {30638-30643},
timestamp = {2019-12-04T03:58:17.000+0100},
title = {Site Activation Effects Promoted by Intramolecular Hydrogen Bond Interactions in Snar Reactions},
type = {Journal Article},
url = {/brokenurl#<Go to ISI>://WOS:000340500300025},
volume = 4,
year = 2014
}