%0 Journal Article %1 WOS:000443580100009 %A Tessarolo, Louise Donadello %A de Menezes, Ramon Roseo Paula Pessoa Bezerra %A Mello, Clarissa Perdigao %A Lim, Danya Bandeira %A Magalhaes, Emanuel Paula %A Bezerra, Eveline Matias %A Sales, Francisco Adilson Matos %A Neto, Ito Liberato Barroso %A de Oliveira, Maria Fatima %A dos Santos, Ricardo Pires %A Albuquerque, Eudenilson L %A Freire, Valder Nogueira %A Martins, Alice Maria %C 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA %D 2018 %I CAMBRIDGE UNIV PRESS %J PARASITOLOGY %K Chagas Trypanosoma calcium carbonate; cruzi} disease; nanoparticles; {Benznidazole; %N 9 %P 1191-1198 %R 10.1017/S0031182018000197 %T Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi %V 145 %X Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.

@article{WOS:000443580100009, abstract = {Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA}, author = {Tessarolo, Louise Donadello and de Menezes, Ramon Roseo Paula Pessoa Bezerra and Mello, Clarissa Perdigao and Lim, Danya Bandeira and Magalhaes, Emanuel Paula and Bezerra, Eveline Matias and Sales, Francisco Adilson Matos and Neto, Ito Liberato Barroso and de Oliveira, Maria Fatima and dos Santos, Ricardo Pires and Albuquerque, Eudenilson L and Freire, Valder Nogueira and Martins, Alice Maria}, biburl = {https://www.bibsonomy.org/bibtex/28c6057cb5002650ee86cee3b303f0152/ppgfis_ufc_br}, doi = {10.1017/S0031182018000197}, interhash = {2c0f1848b996615f885274977758bb4b}, intrahash = {8c6057cb5002650ee86cee3b303f0152}, issn = {0031-1820}, journal = {PARASITOLOGY}, keywords = {Chagas Trypanosoma calcium carbonate; cruzi} disease; nanoparticles; {Benznidazole;}, number = 9, pages = {1191-1198}, publisher = {CAMBRIDGE UNIV PRESS}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi}, tppubtype = {article}, volume = 145, year = 2018 }