Silicon (Si) microstructures are fabricated comprising a micro-aperture in a silicon nitride membrane connecting two microfluidic compartments. Dielectrophoretic forces are created on-chip, which guide the passage of single CHO cells through the microaperture. When a cell dielectrophoretically traverses the aperture, there is a decrease in the background ionic current. These current fluctuations are recorded under varying cell concentrations, micro-aperture sizes, and applied voltages. This work shows the feasibility of building silicon-based bioparticle detectors with nanoscale apertures for sensing the translocation of cells, proteins, and even single-stranded DNA.
%0 Generic
%1 pandey_detection_2004
%A Pandey, S.
%A White, M.H.
%B The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
%D 2004
%I IEEE
%K Apertures, Microfluidics, Microstructure, Silicon, Voltage, aperture, cell counter, dielectrophoresis, electrical field microfluidics myown
%P 1956--1959
%R 10.1109/IEMBS.2004.1403578
%T Detection of dielectrophoretic driven passage of single cells through micro-apertures in a silicon nitride membrane
%U https://www.ece.iastate.edu/pandey/publications/
%V 1
%X Silicon (Si) microstructures are fabricated comprising a micro-aperture in a silicon nitride membrane connecting two microfluidic compartments. Dielectrophoretic forces are created on-chip, which guide the passage of single CHO cells through the microaperture. When a cell dielectrophoretically traverses the aperture, there is a decrease in the background ionic current. These current fluctuations are recorded under varying cell concentrations, micro-aperture sizes, and applied voltages. This work shows the feasibility of building silicon-based bioparticle detectors with nanoscale apertures for sensing the translocation of cells, proteins, and even single-stranded DNA.
@conference{pandey_detection_2004,
abstract = {Silicon (Si) microstructures are fabricated comprising a micro-aperture in a silicon nitride membrane connecting two microfluidic compartments. Dielectrophoretic forces are created on-chip, which guide the passage of single CHO cells through the microaperture. When a cell dielectrophoretically traverses the aperture, there is a decrease in the background ionic current. These current fluctuations are recorded under varying cell concentrations, micro-aperture sizes, and applied voltages. This work shows the feasibility of building silicon-based bioparticle detectors with nanoscale apertures for sensing the translocation of cells, proteins, and even single-stranded DNA.},
added-at = {2022-07-12T23:10:12.000+0200},
author = {Pandey, S. and White, M.H.},
biburl = {https://www.bibsonomy.org/bibtex/2b2b22489d7c080a7d220e42e1c344cd2/spandey50},
booktitle = {The 26th {Annual} {International} {Conference} of the {IEEE} {Engineering} in {Medicine} and {Biology} {Society}},
doi = {10.1109/IEMBS.2004.1403578},
interhash = {4348c4a9175ef303c00578684835ab37},
intrahash = {b2b22489d7c080a7d220e42e1c344cd2},
keywords = {Apertures, Microfluidics, Microstructure, Silicon, Voltage, aperture, cell counter, dielectrophoresis, electrical field microfluidics myown},
language = {en},
month = sep,
pages = {1956--1959},
publisher = {IEEE},
timestamp = {2023-02-23T21:17:40.000+0100},
title = {Detection of dielectrophoretic driven passage of single cells through micro-apertures in a silicon nitride membrane},
url = {https://www.ece.iastate.edu/pandey/publications/},
volume = 1,
year = 2004
}