Vascular endothelial growth factor (VEGF) receptors consist of three cell-membrane type receptors (VEGFR-1, VEGFR-2 and VEGFR-3), and soluble form of VEGFR-1 (sVEGFR-1), an intrinsic negative counterpart of the VEGF. In this study, we measured intratumoral protein levels of free and total VEGF, VEGFR-2 and sVEGFR-1 from 202 primary breast cancer tissues and examined their prognostic values. A significant inverse correlation was found between free or total VEGF and oestrogen receptor (ER) status (P=0.042 and 0.032, respectively). A univariate analysis showed that low sVEGFR-1 and high total VEGF were significantly associated with poor prognosis in disease-free survival (DFS) and overall survival (OS). The ratio of sVEGFR-1 to total VEGF was a strong prognostic indicator (DFS: P=0.008; OS: P=0.0002). A multivariate analysis confirmed the independent prognostic values of total VEGF and the ratio of sVEGFR-1 to total VEGF. In subgroup analysis, total VEGF was a significant prognostic indic
%0 Journal Article
%1 Bando.2005
%A Bando, H.
%A Weich, H. A.
%A Brokelmann, M.
%A Horiguchi, S.
%A Funata, N.
%A Ogawa, T.
%A Toi, M.
%D 2005
%J Br.J.Cancer
%K Adult Aged Analysis Assay Breast Disease-Free Endothelial Enzyme-Linked Factor Factors Female Growth Humans Immunosorbent Japan Middle Multivariate Neoplasms Neovascularization Physiologic Prognosis Receptor-1 Receptor-2 Research Survival Vascular analysis metabolism protein
%N 3
%P 553-561
%T Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer
%U PM:15668703
%V 92
%X Vascular endothelial growth factor (VEGF) receptors consist of three cell-membrane type receptors (VEGFR-1, VEGFR-2 and VEGFR-3), and soluble form of VEGFR-1 (sVEGFR-1), an intrinsic negative counterpart of the VEGF. In this study, we measured intratumoral protein levels of free and total VEGF, VEGFR-2 and sVEGFR-1 from 202 primary breast cancer tissues and examined their prognostic values. A significant inverse correlation was found between free or total VEGF and oestrogen receptor (ER) status (P=0.042 and 0.032, respectively). A univariate analysis showed that low sVEGFR-1 and high total VEGF were significantly associated with poor prognosis in disease-free survival (DFS) and overall survival (OS). The ratio of sVEGFR-1 to total VEGF was a strong prognostic indicator (DFS: P=0.008; OS: P=0.0002). A multivariate analysis confirmed the independent prognostic values of total VEGF and the ratio of sVEGFR-1 to total VEGF. In subgroup analysis, total VEGF was a significant prognostic indic
@article{Bando.2005,
abstract = {Vascular endothelial growth factor (VEGF) receptors consist of three cell-membrane type receptors (VEGFR-1, VEGFR-2 and VEGFR-3), and soluble form of VEGFR-1 (sVEGFR-1), an intrinsic negative counterpart of the VEGF. In this study, we measured intratumoral protein levels of free and total VEGF, VEGFR-2 and sVEGFR-1 from 202 primary breast cancer tissues and examined their prognostic values. A significant inverse correlation was found between free or total VEGF and oestrogen receptor (ER) status (P=0.042 and 0.032, respectively). A univariate analysis showed that low sVEGFR-1 and high total VEGF were significantly associated with poor prognosis in disease-free survival (DFS) and overall survival (OS). The ratio of sVEGFR-1 to total VEGF was a strong prognostic indicator (DFS: P=0.008; OS: P=0.0002). A multivariate analysis confirmed the independent prognostic values of total VEGF and the ratio of sVEGFR-1 to total VEGF. In subgroup analysis, total VEGF was a significant prognostic indic},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Bando, H. and Weich, H. A. and Brokelmann, M. and Horiguchi, S. and Funata, N. and Ogawa, T. and Toi, M.},
biburl = {https://www.bibsonomy.org/bibtex/297a93b9f0ef7a7722b4b9b04fb69cb6e/kanefendt},
interhash = {531261c5eaffb88b54b5fe8fbde0719f},
intrahash = {97a93b9f0ef7a7722b4b9b04fb69cb6e},
journal = {Br.J.Cancer},
keywords = {Adult Aged Analysis Assay Breast Disease-Free Endothelial Enzyme-Linked Factor Factors Female Growth Humans Immunosorbent Japan Middle Multivariate Neoplasms Neovascularization Physiologic Prognosis Receptor-1 Receptor-2 Research Survival Vascular analysis metabolism protein},
number = 3,
pages = {553-561},
timestamp = {2010-02-05T11:28:42.000+0100},
title = {Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer},
url = {PM:15668703},
volume = 92,
year = 2005
}