%0 Journal Article %1 ISI:000226839500003 %A Karplus, M %A Gao, YQ %A Ma, JP %A van der Vaart, A %A Yang, W %C 6 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND %D 2005 %I ROYAL SOC LONDON %J PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES %K analysis based energy landscape %N 1827 %P 331-355 %R 10.1098/rsta.2004.1496 %T Protein structural transitions and their functional role %V 363 %X Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F-1-ATPase, a motor protein which synthesizes and hydrolyses ATP.

@article{ISI:000226839500003, abstract = {{Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F-1-ATPase, a motor protein which synthesizes and hydrolyses ATP.}}, added-at = {2009-01-14T02:32:13.000+0100}, address = {{6 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND}}, affiliation = {{Karplus, M (Reprint Author), Univ Strasbourg 1, ISIS, Lab Chim Biophys, F-67000 Strasbourg, France. Univ Strasbourg 1, ISIS, Lab Chim Biophys, F-67000 Strasbourg, France. Harvard Univ, Dept Chem \& Biol Chem, Cambridge, MA 02138 USA. Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA.}}, author = {Karplus, M and Gao, YQ and Ma, JP and van der Vaart, A and Yang, W}, author-email = {{marci@tammy.harvard.edu}}, biburl = {https://www.bibsonomy.org/bibtex/245ef1bf298d3c62e4a73823afd5d7e95/huiyangsfsu}, cited-references = {{ABRAHAMS JP, 1994, NATURE, V370, P621. ALBERTS B, 1998, CELL, V92, P291. ALLISON WS, 1998, ACCOUNTS CHEM RES, V31, P819. ANFINSEN CB, 1973, SCIENCE, V181, P223. ANTES I, 2003, BIOPHYS J, V85, P695. AUSTIN RH, 1975, BIOCHEMISTRY-US, V14, P5355. BERG HC, 2003, REV BIOCH, V72, P19. BETANCOURT MR, 1999, J MOL BIOL, V287, P627. BOCKMANN RA, 2002, NAT STRUCT BIOL, V9, P198. BOCKMANN RA, 2003, BIOPHYS J, V85, P1482. BOISVERT DC, 1996, NAT STRUCT BIOL, V3, P170. BOYER PD, 1979, MEMBRANE BIOENERGETI, P461. BOYER PD, 1993, BIOCHIM BIOPHYS ACTA, V1140, P215. BOYER PD, 1997, ANNU REV BIOCHEM, V66, P717. BOYER PD, 2002, J BIOL CHEM, V277, P39045, DOI 10.1074/jbc.X200001200. BRAIG K, 1994, NATURE, V371, P578. 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WEISSMAN JS, 1996, CELL, V84, P481. WOLNES PG, 2005, PHIL T R SOC A, V363, P453. XU ZH, 1997, NATURE, V388, P741. YANG W, 2003, P NATL ACAD SCI USA, V100, P874, DOI 10.1073/pnas.0337432100. YASUDA R, 1998, CELL, V93, P1117. YASUDA R, 2001, NATURE, V410, P898. ZAHN R, 1996, J MOL BIOL, V261, P43. ZAHN R, 1996, SCIENCE, V271, P642.}}, doc-delivery-number = {{895CW}}, doi = {{10.1098/rsta.2004.1496}}, interhash = {043de25ac8b2c5826cbddde8607f9a29}, intrahash = {45ef1bf298d3c62e4a73823afd5d7e95}, issn = {{1364-503X}}, journal = {{PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES}}, journal-iso = {{Philos. Trans. R. Soc. Lond. Ser. A-Math. Phys. Eng. Sci.}}, keywords = {analysis based energy landscape}, keywords-plus = {{MOLECULAR-DYNAMICS SIMULATION; BACTERIAL CHAPERONIN GROEL; ATP SYNTHASE; CRYSTAL-STRUCTURE; CONFORMATIONAL CHANGE; ENERGY TRANSDUCTION; ANGSTROM RESOLUTION; CATALYTIC SITES; CRYOELECTRON MICROSCOPY; ALLOSTERIC MECHANISM}}, language = {{English}}, month = {{FEB 15}}, number = {{1827}}, number-of-cited-references = {{104}}, pages = {{331-355}}, publisher = {{ROYAL SOC LONDON}}, subject-category = {{Multidisciplinary Sciences}}, times-cited = {{10}}, timestamp = {2009-01-14T02:32:13.000+0100}, title = {{Protein structural transitions and their functional role}}, type = {{Article}}, unique-id = {{ISI:000226839500003}}, volume = {{363}}, year = {{2005}} }