Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40\% of etiologically undiagnosed cases of CP in the community (48\% of those born at term and 24\% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60\% of maturely born hemiplegics, 45\% of maturely born spastic diplegics, 32\% of premature spastic diplegics and virtually all cases of pure ataxia. About 23\% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37\% is characterized by a single risk factor, usually perinatal.
%0 Journal Article
%1 Costeff2004
%A Costeff, H.
%D 2004
%J Ann Hum Genet
%K Adult; Birth Injuries; Brain Cerebral Palsy; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Premature Birth; Risk Factors; Sweden
%N Pt 5
%P 515--520
%R 10.1046/j.1529-8817.2004.00105.x
%T Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden.
%U http://dx.doi.org/10.1046/j.1529-8817.2004.00105.x
%V 68
%X Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40\% of etiologically undiagnosed cases of CP in the community (48\% of those born at term and 24\% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60\% of maturely born hemiplegics, 45\% of maturely born spastic diplegics, 32\% of premature spastic diplegics and virtually all cases of pure ataxia. About 23\% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37\% is characterized by a single risk factor, usually perinatal.
@article{Costeff2004,
abstract = {Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40\% of etiologically undiagnosed cases of CP in the community (48\% of those born at term and 24\% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60\% of maturely born hemiplegics, 45\% of maturely born spastic diplegics, 32\% of premature spastic diplegics and virtually all cases of pure ataxia. About 23\% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37\% is characterized by a single risk factor, usually perinatal.},
added-at = {2014-07-19T19:16:26.000+0200},
author = {Costeff, H.},
biburl = {https://www.bibsonomy.org/bibtex/230523a363bdae7b858096fdb078a6f37/ar0berts},
doi = {10.1046/j.1529-8817.2004.00105.x},
groups = {public},
interhash = {9fd02eb563ea368f95ef86689edfb171},
intrahash = {30523a363bdae7b858096fdb078a6f37},
journal = {Ann Hum Genet},
keywords = {Adult; Birth Injuries; Brain Cerebral Palsy; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Premature Birth; Risk Factors; Sweden},
month = Sep,
number = {Pt 5},
pages = {515--520},
pii = {AHG105},
pmid = {15469428},
timestamp = {2014-07-19T19:16:26.000+0200},
title = {Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden.},
url = {http://dx.doi.org/10.1046/j.1529-8817.2004.00105.x},
username = {ar0berts},
volume = 68,
year = 2004
}