An institutional analysis of the correlation between KI 67 index and other prognostic markers in invasive breast cancer in northern province, Sri Lanka
Introduction: Breast cancer is the commonest cancer among females in Sri Lanka. The markers that define the treatment recommendations are Estrogen receptors (ER) status, Progesterone receptor (PR) status, HER-2 neu and Ki-67 proliferative index.
Methodology: This is a retrospective study performed on the pathological specimens of invasive ductal carcinoma at Teaching Hospital Jaffna from January 2020 to July 2022. Ki-67 index above 20 was considered high and below 20 as low. The correlation between Ki-67 and other prognostic markers was analyzed as categorical variables using chi-square test.
Results: 143 specimens were analyzed, of which 101 were core biopsies and 42 were mastectomy/ WLE specimens. ER, PR and HER2/neu positivity were noted in 100 (69.9%), 85 (59.4%) and 41(28.7%) cases, respectively. Nottingham tumour grade 1,2 and 3 was noted in 16 (11.2%), 74 (51.7%) and 38 (26.6%) cases, respectively. The mean Ki-67 index was 40.21 %. High Ki-67 index was noted in 107(74.8%) and low in 36(25.2%) cases. A significant correlation was noted between ER, PR positivity and Ki-67 index (p=0.02, 0.01). The correlation between HER2/neu positivity and Ki-67 was insignificant (p=0.06). A significant correlation was found between the Ki-67 index and tumour grade (p=0.01).
Conclusion: This study showed that high Ki-67 expression is associated with high tumour grade, ER/PR positivity and HER2/neu negativity. Varying results with the published literature reveal geographical variations and warrant large-scale analysis with a bigger sample size.
%0 Journal Article
%1 sivakumaran_gobinath_2024_10615010
%A Gobinath, Sivakumaran
%A Rajendra, Sittampalam
%A Theepan, Jathavani Mariyo Maznet
%A Gobishangar, Sreekanthan
%A Vaishnavi, Sakthivel
%A Hamsavakini, Nadarasa
%A Shathana, Paramanathan
%D 2024
%J GSC Advanced Research and Reviews
%K Invasive breast cancer
%N 2
%P 157–161
%R 10.30574/gscarr.2023.17.2.0424
%T An institutional analysis of the correlation between KI 67 index and other prognostic markers in invasive breast cancer in northern province, Sri Lanka
%U https://gsconlinepress.com/journals/gscarr/content/institutional-analysis-correlation-between-ki-67-index-and-other-prognostic-markers-invasive
%V 17
%X Introduction: Breast cancer is the commonest cancer among females in Sri Lanka. The markers that define the treatment recommendations are Estrogen receptors (ER) status, Progesterone receptor (PR) status, HER-2 neu and Ki-67 proliferative index.
Methodology: This is a retrospective study performed on the pathological specimens of invasive ductal carcinoma at Teaching Hospital Jaffna from January 2020 to July 2022. Ki-67 index above 20 was considered high and below 20 as low. The correlation between Ki-67 and other prognostic markers was analyzed as categorical variables using chi-square test.
Results: 143 specimens were analyzed, of which 101 were core biopsies and 42 were mastectomy/ WLE specimens. ER, PR and HER2/neu positivity were noted in 100 (69.9%), 85 (59.4%) and 41(28.7%) cases, respectively. Nottingham tumour grade 1,2 and 3 was noted in 16 (11.2%), 74 (51.7%) and 38 (26.6%) cases, respectively. The mean Ki-67 index was 40.21 %. High Ki-67 index was noted in 107(74.8%) and low in 36(25.2%) cases. A significant correlation was noted between ER, PR positivity and Ki-67 index (p=0.02, 0.01). The correlation between HER2/neu positivity and Ki-67 was insignificant (p=0.06). A significant correlation was found between the Ki-67 index and tumour grade (p=0.01).
Conclusion: This study showed that high Ki-67 expression is associated with high tumour grade, ER/PR positivity and HER2/neu negativity. Varying results with the published literature reveal geographical variations and warrant large-scale analysis with a bigger sample size.
@article{sivakumaran_gobinath_2024_10615010,
abstract = {Introduction: Breast cancer is the commonest cancer among females in Sri Lanka. The markers that define the treatment recommendations are Estrogen receptors (ER) status, Progesterone receptor (PR) status, HER-2 neu and Ki-67 proliferative index.
Methodology: This is a retrospective study performed on the pathological specimens of invasive ductal carcinoma at Teaching Hospital Jaffna from January 2020 to July 2022. Ki-67 index above 20 was considered high and below 20 as low. The correlation between Ki-67 and other prognostic markers was analyzed as categorical variables using chi-square test.
Results: 143 specimens were analyzed, of which 101 were core biopsies and 42 were mastectomy/ WLE specimens. ER, PR and HER2/neu positivity were noted in 100 (69.9%), 85 (59.4%) and 41(28.7%) cases, respectively. Nottingham tumour grade 1,2 and 3 was noted in 16 (11.2%), 74 (51.7%) and 38 (26.6%) cases, respectively. The mean Ki-67 index was 40.21 %. High Ki-67 index was noted in 107(74.8%) and low in 36(25.2%) cases. A significant correlation was noted between ER, PR positivity and Ki-67 index (p=0.02, 0.01). The correlation between HER2/neu positivity and Ki-67 was insignificant (p=0.06). A significant correlation was found between the Ki-67 index and tumour grade (p=0.01).
Conclusion: This study showed that high Ki-67 expression is associated with high tumour grade, ER/PR positivity and HER2/neu negativity. Varying results with the published literature reveal geographical variations and warrant large-scale analysis with a bigger sample size.},
added-at = {2024-03-14T11:49:18.000+0100},
author = {Gobinath, Sivakumaran and Rajendra, Sittampalam and Theepan, Jathavani Mariyo Maznet and Gobishangar, Sreekanthan and Vaishnavi, Sakthivel and Hamsavakini, Nadarasa and Shathana, Paramanathan},
biburl = {https://www.bibsonomy.org/bibtex/20daa86ac6346bbebf58e5e0e644f020b/gscarrjournal},
doi = {10.30574/gscarr.2023.17.2.0424},
interhash = {3129e109efbf4f786ea56e761725fee1},
intrahash = {0daa86ac6346bbebf58e5e0e644f020b},
issn = {2582-4597},
journal = {GSC Advanced Research and Reviews},
keywords = {Invasive breast cancer},
month = feb,
number = 2,
pages = {157–161},
timestamp = {2024-03-14T11:49:18.000+0100},
title = {An institutional analysis of the correlation between KI 67 index and other prognostic markers in invasive breast cancer in northern province, Sri Lanka},
url = {https://gsconlinepress.com/journals/gscarr/content/institutional-analysis-correlation-between-ki-67-index-and-other-prognostic-markers-invasive},
volume = 17,
year = 2024
}