Synthesis and Characterization of New 2-Thiophen 3'4-Dimethylbenzaldehyde as 3,4-Dihydropyrimidinone Derivatives
CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (5):
33-37 (September 2023)Abstract
Background: This study it has been successfully synthesized and characterized in the form of 3,4-dihydropyrimidin-2-(1H) ones (1-3) a derivative. This compound were synthesized by reaction of 1,3-cyclohexane dione in the presence of ethanol, urea, and aromatic aldehyde(t-BuOK).It has been characterized spectroscopically (For example, 13C-NMR, 1H-NMR, and FT-IR) For the purpose of showing the chemical composition and the final result of the industrial compound.
Methods: The design of this research was cross-sectional. descriptive investigation,which included the preparation of a group of polypyrimidine derivatives.
Results: In the current work, 1,3-cyclohexandione, aromatic aldehydes, and urea are combined with ethanol to create 3,4-Dihydropyrimidine. The chemical composition of molecules was determined via spectral analysis (1-2)a.
Conclusion: When t-BuOK was used as a catalyst in this work to create three DHMP compounds, it produced outstanding results with a high yield and a quicker reaction time than the assistant factor.